DCTN4

Protein-coding gene in humans

DCTN4
Identifiers
AliasesDCTN4, DYN4, P62, dynactin subunit 4
External IDsOMIM: 614758; MGI: 1914915; HomoloGene: 9430; GeneCards: DCTN4; OMA:DCTN4 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for DCTN4
Genomic location for DCTN4
Band5q33.1Start150,708,440 bp[1]
End150,759,095 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for DCTN4
Genomic location for DCTN4
Band18|18 D3Start60,659,257 bp[2]
End60,691,838 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • biceps brachii

  • Skeletal muscle tissue of rectus abdominis

  • Skeletal muscle tissue of biceps brachii

  • retinal pigment epithelium

  • tail of epididymis

  • corpus epididymis

  • lactiferous duct

  • pars reticulata

  • Pars compacta

  • caput epididymis
Top expressed in
  • genital tubercle

  • cumulus cell

  • pineal gland

  • tail of embryo

  • supraoptic nucleus

  • ciliary body

  • renal corpuscle

  • aortic valve

  • medullary collecting duct

  • retinal pigment epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein N-terminus binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • cytoplasmic dynein complex
  • cytoskeleton
  • nucleus
  • dynactin complex
  • microtubule organizing center
  • kinetochore
  • spindle pole
  • stress fiber
  • focal adhesion
  • cell cortex
  • sarcomere
Biological process
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • nuclear migration
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51164

67665

Ensembl

ENSG00000132912

ENSMUSG00000024603

UniProt

Q9UJW0

Q8CBY8

RefSeq (mRNA)

NM_001135643
NM_001135644
NM_016221

NM_026302
NM_001357462

RefSeq (protein)

NP_001129115
NP_001129116
NP_057305

NP_080578
NP_001344391

Location (UCSC)Chr 5: 150.71 – 150.76 MbChr 18: 60.66 – 60.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynactin subunit 4 is a protein that in humans is encoded by the DCTN4 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132912 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024603 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Dynactin 4 (p62)".

Further reading

  • Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
  • Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, Gibson RL, Bamshad MJ (July 2012). "Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis". Nature Genetics. 44 (8): 886–9. doi:10.1038/ng.2344. PMC 3702264. PMID 22772370.
  • Ayalon G, Davis JQ, Scotland PB, Bennett V (December 2008). "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan". Cell. 135 (7): 1189–200. doi:10.1016/j.cell.2008.10.018. PMID 19109891. S2CID 17268857.
  • Bingham JB, Schroer TA (February 1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology. 9 (4): 223–6. Bibcode:1999CBio....9..223B. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429. S2CID 208851.
  • Lim CM, Cater MA, Mercer JF, La Fontaine S (May 2006). "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A". The Journal of Biological Chemistry. 281 (20): 14006–14. doi:10.1074/jbc.M512745200. hdl:10536/DRO/DU:30003771. PMID 16554302.
  • Boultwood J, Fidler C, Strickson AJ, Watkins F, Kostrzewa M, Jaju RJ, Müller U, Wainscoat JS (May 2000). "Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs". Genomics. 66 (1): 26–34. doi:10.1006/geno.2000.6193. PMID 10843801.
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