DCUN1D4

Protein-coding gene in the species Homo sapiens
DCUN1D4
Identifiers
AliasesDCUN1D4, defective in cullin neddylation 1 domain containing 4, DCNL4
External IDsOMIM: 612977; MGI: 2140972; HomoloGene: 22867; GeneCards: DCUN1D4; OMA:DCUN1D4 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for DCUN1D4
Genomic location for DCUN1D4
Band4q12Start51,843,000 bp[1]
End51,916,837 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for DCUN1D4
Genomic location for DCUN1D4
Band5|5 C3.3Start73,638,343 bp[2]
End73,718,137 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • epithelium of colon

  • germinal epithelium

  • testicle

  • left ovary

  • right ovary

  • tail of epididymis

  • popliteal artery

  • gastric mucosa

  • tibial arteries
Top expressed in
  • spermatid

  • visual cortex

  • lateral hypothalamus

  • amygdala

  • primary visual cortex

  • superior frontal gyrus

  • ventromedial nucleus

  • zygote

  • genital tubercle

  • yolk sac
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • cullin family protein binding
  • ubiquitin-like protein binding
  • protein binding
  • ubiquitin conjugating enzyme binding
  • molecular function
Cellular component
  • nucleus
  • ubiquitin ligase complex
Biological process
  • protein neddylation
  • positive regulation of ubiquitin-protein transferase activity
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23142

100737

Ensembl

ENSG00000109184

ENSMUSG00000051674

UniProt

Q92564

Q8CCA0

RefSeq (mRNA)

NM_001040402
NM_001287755
NM_001287757
NM_015115

NM_001190733
NM_001190734
NM_178896

RefSeq (protein)

NP_001035492
NP_001274684
NP_001274686
NP_055930

NP_001177662
NP_001177663
NP_849227

Location (UCSC)Chr 4: 51.84 – 51.92 MbChr 5: 73.64 – 73.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DCN1-like protein 4 is a protein that in humans is encoded by the DCUN1D4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109184 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051674 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kurz T, Ozlu N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. Bibcode:2005Natur.435.1257K. doi:10.1038/nature03662. PMID 15988528. S2CID 4328225.
  6. ^ "Entrez Gene: DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)".

Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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