DDX11 |
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Identifiers |
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Aliases | DDX11, CHL1, CHLR1, KRG2, WABS, DEAD/H-box helicase 11 |
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External IDs | OMIM: 601150; MGI: 2443590; HomoloGene: 68973; GeneCards: DDX11; OMA:DDX11 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12p11.21 | Start | 31,073,860 bp[1] |
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End | 31,104,799 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17|17 E1.1 | Start | 66,430,515 bp[2] |
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End | 66,459,169 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of transverse colon
- body of pancreas
- left ovary
- body of uterus
- right ovary
- apex of heart
- lymph node
- left testis
- ventricular zone
- spleen
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| Top expressed in | - primary oocyte
- hand
- spermatocyte
- secondary oocyte
- Paneth cell
- zygote
- epiblast
- ventricular zone
- tail of embryo
- renal corpuscle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - 4 iron, 4 sulfur cluster binding
- nucleotide binding
- helicase activity
- iron-sulfur cluster binding
- metal ion binding
- single-stranded DNA binding
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- protein binding
- RNA binding
- nucleic acid binding
- double-stranded DNA binding
- hydrolase activity
- ATP binding
- DNA binding
- chromatin binding
- DNA replication origin binding
- single-stranded RNA binding
- DNA helicase activity
- ATP-dependent activity, acting on DNA
- ATP-dependent activity, acting on RNA
- triplex DNA binding
- G-quadruplex DNA binding
| Cellular component | - nucleolus
- extracellular exosome
- nucleus
- spindle pole
- fibrillar center
- nucleoplasm
- chromosome
- cytoplasm
- centrosome
- microtubule organizing center
- cytoskeleton
- midbody
- mitotic cohesin complex
- Ctf18 RFC-like complex
| Biological process | - sister chromatid cohesion
- IRE1-mediated unfolded protein response
- viral process
- nucleobase-containing compound metabolic process
- DNA replication
- DNA repair
- transcription, DNA-templated
- regulation of transcription, DNA-templated
- cellular response to DNA damage stimulus
- multicellular organism development
- replication fork processing
- positive regulation of endodeoxyribonuclease activity
- negative regulation of protein binding
- DNA duplex unwinding
- positive regulation of chromatin binding
- G-quadruplex DNA unwinding
- positive regulation of sister chromatid cohesion
- cellular response to hydroxyurea
- cellular response to cisplatin
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
- cellular response to bleomycin
- nucleolar chromatin organization
- positive regulation of double-strand break repair
- establishment of sister chromatid cohesion
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001257144 NM_001257145 NM_004399 NM_030653 NM_030655
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NM_152438 |
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RefSeq (protein) | |
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NP_001244073 NP_001244074 NP_004390 NP_085911 NP_689651 |
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Location (UCSC) | Chr 12: 31.07 – 31.1 Mb | Chr 17: 66.43 – 66.46 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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