Protein-coding gene in the species Homo sapiens
DHRS7 |
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Identifiers |
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Aliases | DHRS7, SDR34C1, retDSR4, retSDR4, CGI-86, dehydrogenase/reductase (SDR family) member 7, dehydrogenase/reductase 7 |
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External IDs | OMIM: 612833; MGI: 1913625; HomoloGene: 9350; GeneCards: DHRS7; OMA:DHRS7 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 14 (human)[1] |
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| Band | 14q23.1 | Start | 60,144,119 bp[1] |
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End | 60,169,856 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 12 (mouse)[2] |
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| Band | 12|12 C3 | Start | 72,697,127 bp[2] |
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End | 72,711,683 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - parotid gland
- gastrocnemius muscle
- Achilles tendon
- muscle of thigh
- left adrenal gland
- blood
- granulocyte
- Descending thoracic aorta
- seminal vesicula
- glutes
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| Top expressed in | - granulocyte
- lacrimal gland
- skin of external ear
- parotid gland
- brown adipose tissue
- lip
- adrenal gland
- Ileal epithelium
- cardiac muscle tissue of left ventricle
- seminal vesicula
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_016029 NM_001322280 NM_001322281 NM_001322282 |
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RefSeq (protein) | |
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NP_001309209 NP_001309210 NP_001309211 NP_057113 |
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Location (UCSC) | Chr 14: 60.14 – 60.17 Mb | Chr 12: 72.7 – 72.71 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Dehydrogenase/reductase (SDR family) member 7 is a protein that in humans is encoded by the DHRS7 gene.[5]
Function
Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids.[6][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100612 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021094 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Dehydrogenase/reductase (SDR family) member 7". Retrieved 2014-04-28.
- ^ Araya S, Kratschmar DV, Tsachaki M, Stücheli S, Beck KR, Odermatt A (July 2017). "DHRS7 (SDR34C1) – A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone?". The Journal of Steroid Biochemistry and Molecular Biology. 171: 288–295. doi:10.1016/j.jsbmb.2017.04.013. PMID 28457967. S2CID 30060280.
- ^ Štambergová H, Zemanová L, Lundová T, Malčeková B, Skarka A, Šaft M, Wsól V (January 2016). "Human DHRS7, promising enzyme in metabolism of steroids and retinoids?". Journal of Steroid Biochemistry and Molecular Biology. 155, Part A (Pt A): 112–119. doi:10.1016/j.jsbmb.2015.09.041. PMID 26466768. S2CID 25848948.
Further reading
- Ramasamy A, Curjuric I, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J, Wjst M, Bircher AJ, Sovio U, Rochat T, Hartikainen AL, Balding DJ, Jarvelin MR, Probst-Hensch N, Strachan DP, Jarvis DL (November 2011). "A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order". The Journal of Allergy and Clinical Immunology. 128 (5): 996–1005. doi:10.1016/j.jaci.2011.08.030. PMID 22036096.
- Štambergová H, Škarydová L, Dunford JE, Wsól V (January 2014). "Biochemical properties of human dehydrogenase/reductase (SDR family) member 7". Chemico-Biological Interactions. 207 (1): 52–7. Bibcode:2014CBI...207...52S. doi:10.1016/j.cbi.2013.11.003. PMID 24246706.
- Skarka A, Škarydová L, Štambergová H, Wsól V (March 2014). "Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells". Protein Expression and Purification. 95: 44–49. doi:10.1016/j.pep.2013.11.013. PMID 24316191.
- Seibert JK, Quagliata L, Quintavalle C, Hammond TG, Terracciano L, Odermatt A (November 2015). "A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer". Cancer Medicine. 4 (11): 1717–1729. doi:10.1002/cam4.517. PMC 4673999. PMID 26311046.
- Zemanová L, Kirubakaran P, Pato IH, Štambergová H, Vondrášek J (December 2017). "The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing". International Journal of Biological Macromolecules. 105, Part 1 (Pt 1): 171–182. doi:10.1016/j.ijbiomac.2017.07.012. PMID 28687384.
- Stücheli S, Araya S, Ercan C, Moser SO, Gallon J, Jenö P, Piscuoglio S, Terracciano L, Odermatt A (June 2022). "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples". Cancers (Basel). 14 (13): 3074. doi:10.3390/cancers14133074. PMC 9264982. PMID 35804847.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.