DIDS
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Preferred IUPAC name 2,2′-(Ethene-1,2-diyl)bis(5-isothiocyanatobenzene-1-sulfonic acid) | |
Other names 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid | |
Identifiers | |
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3D model (JSmol) |
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Abbreviations | DIDS |
Beilstein Reference | 6543839 |
ChEBI |
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ChemSpider |
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ECHA InfoCard | 100.152.489 |
IUPHAR/BPS |
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KEGG |
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MeSH | 4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid |
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InChI
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Properties | |
Chemical formula | C16H10N2O6S4 |
Molar mass | 454.50 g·mol−1 |
Melting point | 400 °C (752 °F; 673 K) |
log P | 4.72 |
Acidity (pKa) | -3.21, -1.428, -0.37, 0.23 |
Basicity (pKb) | 13.77, 14.37, 15.425, 17.21 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor,[1] blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.[2]
References
- ^ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology, 92 (3): 195–205, doi:10.1007/BF01869388, PMID 3783658, S2CID 19244281
- ^ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction, 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526
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EAATsTooltip Excitatory amino acid transporters |
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vGluTsTooltip Vesicular glutamate transporters |
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GAHTooltip Glutamine aminohydrolase (glutaminase) |
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ASTTooltip Aspartate aminotransferase |
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ALTTooltip Alanine aminotransferase |
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GDHTooltip Glutamate dehydrogenase |
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GSTooltip Glutamine synthetase | |
GADTooltip Glutamate decarboxylase |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators
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