DMG-PEG 2000
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Names | |
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IUPAC name 1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol | |
Other names PEG-DMG | |
Identifiers | |
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3D model (JSmol) |
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InChI
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Properties | |
Chemical formula | C122H242O50 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines,[1] and in particular forms part of the drug delivery system for the Moderna COVID-19 vaccine.[2]
See also
- Moderna COVID-19 vaccine nanoparticle ingredients
- Distearoylphosphatidylcholine
- SM-102
- Cholesterol
References
- ^ Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H (2018). "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin. 41 (8): 1291–1294. doi:10.1248/bpb.b18-00208. PMID 30068880.
- ^ "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).