DMTF1

Protein-coding gene in the species Homo sapiens
DMTF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2LLK

Identifiers
AliasesDMTF1, DMP1, DMTF, MRUL, hDMP1, cyclin D binding myb like transcription factor 1
External IDsOMIM: 608491; MGI: 1344415; HomoloGene: 8017; GeneCards: DMTF1; OMA:DMTF1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for DMTF1
Genomic location for DMTF1
Band7q21.12Start87,152,361 bp[1]
End87,196,337 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for DMTF1
Genomic location for DMTF1
Band5|5 A1Start9,168,801 bp[2]
End9,211,776 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right ovary

  • left ovary

  • right uterine tube

  • body of uterus

  • Achilles tendon

  • right hemisphere of cerebellum

  • canal of the cervix

  • ventricular zone
Top expressed in
  • Rostral migratory stream

  • genital tubercle

  • tail of embryo

  • saccule

  • dermis

  • cerebellar vermis

  • human fetus

  • lobe of cerebellum

  • granulocyte

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
Cellular component
  • nucleoplasm
  • cytosol
  • nucleus
Biological process
  • cell cycle
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • cell differentiation
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9988

23857

Ensembl

ENSG00000135164

ENSMUSG00000042508

UniProt

Q9Y222

Q8CE22

RefSeq (mRNA)

NM_001142326
NM_001142327
NM_021145

NM_001110327
NM_011806

RefSeq (protein)

NP_001135798
NP_001135799
NP_066968

NP_001103797
NP_035936

Location (UCSC)Chr 7: 87.15 – 87.2 MbChr 5: 9.17 – 9.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-D-binding Myb-like transcription factor 1 is a protein that in humans is encoded by the DMTF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135164 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042508 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR, Roussel MF, Sherr CJ, Look AT (May 1999). "Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)". Gene. 229 (1–2): 223–8. doi:10.1016/S0378-1119(98)00591-5. PMID 10095122.
  6. ^ "Entrez Gene: DMTF1 cyclin D binding myb-like transcription factor 1".

Further reading

  • Försti A, Angelini S, Festa F, et al. (2004). "Single nucleotide polymorphisms in breast cancer". Oncol. Rep. 11 (4): 917–22. doi:10.3892/or.11.4.917. PMID 15010895.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Tschan MP, Fischer KM, Fung VS, et al. (2003). "Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns". J. Biol. Chem. 278 (44): 42750–60. doi:10.1074/jbc.M307067200. PMID 12917399.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Inoue K, Sherr CJ, Shapiro LH (1998). "Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins". J. Biol. Chem. 273 (44): 29188–94. doi:10.1074/jbc.273.44.29188. PMID 9786929.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Hirai H, Sherr CJ (1996). "Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1". Mol. Cell. Biol. 16 (11): 6457–67. doi:10.1128/MCB.16.11.6457. PMC 231647. PMID 8887674.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.


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