DOK5

Protein-coding gene in the species Homo sapiens
DOK5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1J0W

Identifiers
AliasesDOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDsOMIM: 608334; MGI: 1924079; HomoloGene: 10195; GeneCards: DOK5; OMA:DOK5 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for DOK5
Genomic location for DOK5
Band20q13.2Start54,475,593 bp[1]
End54,651,169 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for DOK5
Genomic location for DOK5
Band2 H3|2 92.26 cMStart170,573,727 bp[2]
End170,721,689 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • pancreatic ductal cell

  • vastus lateralis muscle

  • cartilage tissue

  • Skeletal muscle tissue of rectus abdominis

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • deltoid muscle

  • Brodmann area 46
Top expressed in
  • ventricular zone

  • visual cortex

  • primary visual cortex

  • soleus muscle

  • superior frontal gyrus

  • genital tubercle

  • dentate gyrus of hippocampal formation granule cell

  • neural tube

  • neural layer of retina

  • embryo
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55816

76829

Ensembl

ENSG00000101134

ENSMUSG00000027560

UniProt

Q9P104

Q91ZM9

RefSeq (mRNA)

NM_001294161
NM_018431
NM_177959

NM_001163686
NM_029761

RefSeq (protein)

NP_001281090
NP_060901
NP_808874

NP_001157158
NP_084037

Location (UCSC)Chr 20: 54.48 – 54.65 MbChr 2: 170.57 – 170.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[5][6]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[6]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.[5][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101134 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027560 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (Jul 2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
  6. ^ a b "Entrez Gene: DOK5 docking protein 5".
  7. ^ Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.

Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Shi N, Zhou W, Tang K, et al. (2003). "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D. 58 (Pt 12): 2170–2. doi:10.1107/S090744490201644X. PMID 12454490.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
  • Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
  • Crowder RJ, Enomoto H, Yang M, et al. (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Shi L, Yue J, You Y, et al. (2007). "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.
  • v
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  • e
  • 1j0w: Crystal Structure Analysis of the Dok-5 PTB Domain
    1j0w: Crystal Structure Analysis of the Dok-5 PTB Domain


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