DUSP18

Protein-coding gene in the species Homo sapiens
DUSP18
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ESB

Identifiers
AliasesDUSP18, DSP18, DUSP20, LMWDSP20, bK963H5.1, dual specificity phosphatase 18
External IDsOMIM: 611446; MGI: 1922469; HomoloGene: 34984; GeneCards: DUSP18; OMA:DUSP18 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for DUSP18
Genomic location for DUSP18
Band22q12.2Start30,652,051 bp[1]
End30,667,887 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for DUSP18
Genomic location for DUSP18
Band11|11 A1Start3,845,240 bp[2]
End3,851,296 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • bronchial epithelial cell

  • mucosa of ileum

  • left testis

  • right testis

  • testicle

  • mucosa of paranasal sinus

  • sperm

  • right uterine tube

  • blood
Top expressed in
  • zygote

  • interventricular septum

  • secondary oocyte

  • myocardium of ventricle

  • Rostral migratory stream

  • dentate gyrus of hippocampal formation granule cell

  • lip

  • islet of Langerhans

  • soleus muscle

  • muscle of thigh
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein tyrosine phosphatase activity
  • MAP kinase tyrosine/serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • phosphatase activity
  • protein tyrosine/serine/threonine phosphatase activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleoplasm
  • mitochondrion
  • membrane
  • mitochondrial inner membrane
Biological process
  • protein dephosphorylation
  • peptidyl-tyrosine dephosphorylation
  • peptidyl-threonine dephosphorylation
  • dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

150290

75219

Ensembl

ENSG00000167065

ENSMUSG00000047205

UniProt

Q8NEJ0

Q8VE01

RefSeq (mRNA)

NM_001304794
NM_001304795
NM_001304796
NM_152511

NM_173745

RefSeq (protein)

NP_001291723
NP_001291724
NP_001291725
NP_689724

NP_776106

Location (UCSC)Chr 22: 30.65 – 30.67 MbChr 11: 3.85 – 3.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167065 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hood KL, Tobin JF, Yoon C (Oct 2002). "Identification and characterization of two novel low-molecular-weight dual specificity phosphatases". Biochem Biophys Res Commun. 298 (4): 545–51. doi:10.1016/S0006-291X(02)02488-9. PMID 12408986.
  6. ^ "Entrez Gene: DUSP18 dual specificity phosphatase 18".

Further reading

  • Wu Q, Huang S, Sun Y, et al. (2006). "Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo". Front. Biosci. 11: 2714–24. doi:10.2741/2001. PMID 16720344.
  • Jeong DG, Cho YH, Yoon TS, et al. (2006). "Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family". Acta Crystallogr. D. 62 (Pt 6): 582–8. Bibcode:2006AcCrD..62..582J. doi:10.1107/S0907444906010109. PMID 16699184.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Wu Q, Gu S, Dai J, et al. (2003). "Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain". Biochim. Biophys. Acta. 1625 (3): 296–304. doi:10.1016/s0167-4781(02)00629-2. PMID 12591617.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 18 (DUSP18)


  • v
  • t
  • e
  • 2esb: Crystal structure of human DUSP18
    2esb: Crystal structure of human DUSP18
  • v
  • t
  • e
Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class II
Class III
Class IV


Stub icon

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e