EIF3CL

Protein-coding gene in the species Homo sapiens
EIF3CL
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J8B, 3J8C

Identifiers
AliasesEIF3CL, eukaryotic translation initiation factor 3 subunit C like
External IDsMGI: 1926966; GeneCards: EIF3CL; OMA:EIF3CL - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for EIF3CL
Genomic location for EIF3CL
Band16p12.1Start28,379,579 bp[1]
End28,403,841 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for EIF3CL
Genomic location for EIF3CL
Band7 69.14 cM|7 F3Start126,145,627 bp[2]
End126,165,583 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • left ventricle

  • mucosa of transverse colon

  • epithelium of colon

  • right auricle

  • skeletal muscle tissue

  • gastrocnemius muscle

  • anterior cingulate cortex

  • hippocampus proper

  • gonad
Top expressed in
  • tail of embryo

  • genital tubercle

  • mandibular prominence

  • maxillary prominence

  • somite

  • endothelial cell of lymphatic vessel

  • Gonadal ridge

  • hair follicle

  • primitive streak

  • dermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • translation initiation factor binding
  • translation initiation factor activity
  • RNA binding
Cellular component
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • eukaryotic 43S preinitiation complex
  • eukaryotic 48S preinitiation complex
Biological process
  • translational initiation
  • protein biosynthesis
  • formation of cytoplasmic translation initiation complex
  • cytoplasmic translational initiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

728689

56347

Ensembl

ENSG00000205609

ENSMUSG00000030738

UniProt

B5ME19

Q8R1B4

RefSeq (mRNA)

NM_001099661
NM_001317856
NM_001317857

NM_146200

RefSeq (protein)

NP_001093131
NP_001304785
NP_001304786

NP_666312

Location (UCSC)Chr 16: 28.38 – 28.4 MbChr 7: 126.15 – 126.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. [5]

Function

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205609 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030738 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Eukaryotic translation initiation factor 3 subunit C like". Retrieved 2020-04-15.

Further reading


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.