Protein-coding gene in the species Homo sapiens
EIF3CL |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
3J8B, 3J8C |
|
|
Identifiers |
---|
Aliases | EIF3CL, eukaryotic translation initiation factor 3 subunit C like |
---|
External IDs | MGI: 1926966; GeneCards: EIF3CL; OMA:EIF3CL - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 16 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png) | Chr. | Chromosome 16 (human)[1] |
---|
| Band | 16p12.1 | Start | 28,379,579 bp[1] |
---|
End | 28,403,841 bp[1] |
---|
|
Gene location (Mouse) |
---|
![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
---|
| Band | 7 69.14 cM|7 F3 | Start | 126,145,627 bp[2] |
---|
End | 126,165,583 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - apex of heart
- left ventricle
- mucosa of transverse colon
- epithelium of colon
- right auricle
- skeletal muscle tissue
- gastrocnemius muscle
- anterior cingulate cortex
- hippocampus proper
- gonad
|
| Top expressed in | - tail of embryo
- genital tubercle
- mandibular prominence
- maxillary prominence
- somite
- endothelial cell of lymphatic vessel
- Gonadal ridge
- hair follicle
- primitive streak
- dermis
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - translation initiation factor binding
- translation initiation factor activity
- RNA binding
| Cellular component | - cytoplasm
- eukaryotic translation initiation factor 3 complex
- eukaryotic 43S preinitiation complex
- eukaryotic 48S preinitiation complex
| Biological process | - translational initiation
- protein biosynthesis
- formation of cytoplasmic translation initiation complex
- cytoplasmic translational initiation
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001099661 NM_001317856 NM_001317857 |
| |
---|
RefSeq (protein) | |
---|
NP_001093131 NP_001304785 NP_001304786 |
| |
---|
Location (UCSC) | Chr 16: 28.38 – 28.4 Mb | Chr 7: 126.15 – 126.17 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. [5]
Function
The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000205609 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030738 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Eukaryotic translation initiation factor 3 subunit C like". Retrieved 2020-04-15.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.