ELOVL5

Protein-coding gene in the species Homo sapiens
ELOVL5
Identifiers
AliasesELOVL5, HELO1, SCA38, dJ483K16.1, ELOVL fatty acid elongase 5
External IDsOMIM: 611805; MGI: 1916051; HomoloGene: 41449; GeneCards: ELOVL5; OMA:ELOVL5 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ELOVL5
Genomic location for ELOVL5
Band6p12.1Start53,267,398 bp[1]
End53,349,179 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ELOVL5
Genomic location for ELOVL5
Band9|9 E1Start77,824,646 bp[2]
End77,891,801 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • seminal vesicula

  • secondary oocyte

  • lactiferous duct

  • tibia

  • skin of thigh

  • trigeminal ganglion

  • parietal pleura

  • epithelium of nasopharynx

  • spinal ganglia

  • inferior ganglion of vagus nerve
Top expressed in
  • vestibular membrane of cochlear duct

  • Paneth cell

  • carotid body

  • cumulus cell

  • conjunctival fornix

  • adrenal gland

  • facial motor nucleus

  • substantia nigra

  • stria vascularis

  • anterior horn of spinal cord
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • transferase activity
  • 3-oxo-arachidoyl-CoA synthase activity
  • 3-oxo-cerotoyl-CoA synthase activity
  • fatty acid elongase activity
  • 3-oxo-lignoceronyl-CoA synthase activity
  • very-long-chain 3-ketoacyl-CoA synthase activity
Cellular component
  • dendritic tree
  • dendrite
  • integral component of membrane
  • cell projection
  • endoplasmic reticulum membrane
  • neuronal cell body
  • membrane
  • endoplasmic reticulum
  • integral component of endoplasmic reticulum membrane
Biological process
  • lipid metabolism
  • fatty acid biosynthetic process
  • linoleic acid metabolic process
  • alpha-linolenic acid metabolic process
  • fatty acid metabolic process
  • unsaturated fatty acid biosynthetic process
  • fatty acid elongation, polyunsaturated fatty acid
  • very long-chain fatty acid biosynthetic process
  • fatty acid elongation, monounsaturated fatty acid
  • long-chain fatty-acyl-CoA biosynthetic process
  • positive regulation of fatty acid biosynthetic process
  • fatty acid elongation, saturated fatty acid
  • sphingolipid biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60481

68801

Ensembl

ENSG00000012660

ENSMUSG00000032349

UniProt

Q9NYP7

Q8BHI7

RefSeq (mRNA)

NM_021814
NM_001242828
NM_001242830
NM_001242831
NM_001301856

NM_134255

RefSeq (protein)

NP_001229757
NP_001229759
NP_001229760
NP_001288785
NP_068586

NP_599016

Location (UCSC)Chr 6: 53.27 – 53.35 MbChr 9: 77.82 – 77.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation of very long chain fatty acids protein 5 is a protein that in humans is encoded by the ELOVL5 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000012660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032349 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P (Jan 2001). "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids". Biochem J. 350 Pt 3 (Pt 3): 765–70. doi:10.1042/0264-6021:3500765. PMC 1221308. PMID 10970790.
  6. ^ "Entrez Gene: ELOVL5 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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