EPC1

Protein-coding gene in the species Homo sapiens
EPC1
Identifiers
AliasesEPC1, Epl1, enhancer of polycomb homolog 1
External IDsOMIM: 610999; MGI: 1278322; HomoloGene: 32627; GeneCards: EPC1; OMA:EPC1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for EPC1
Genomic location for EPC1
Band10p11.22Start32,267,751 bp[1]
End32,378,798 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for EPC1
Genomic location for EPC1
Band18|18 A1Start6,435,951 bp[2]
End6,516,108 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • bone marrow cells

  • secondary oocyte

  • pancreatic epithelial cell

  • mucosa of ileum

  • endothelial cell

  • trabecular bone

  • tibialis anterior muscle

  • epithelium of lactiferous gland

  • lactiferous duct
Top expressed in
  • Rostral migratory stream

  • primary oocyte

  • renal corpuscle

  • medullary collecting duct

  • cumulus cell

  • fossa

  • zygote

  • conjunctival fornix

  • condyle

  • external carotid artery
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • histone acetyltransferase activity
  • protein binding
Cellular component
  • Piccolo NuA4 histone acetyltransferase complex
  • nuclear membrane
  • nucleus
  • NuA4 histone acetyltransferase complex
  • nucleoplasm
Biological process
  • vascular associated smooth muscle cell differentiation
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • histone H4 acetylation
  • positive regulation of transcription by RNA polymerase II
  • histone H2A acetylation
  • regulation of transcription by RNA polymerase II
  • positive regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of growth
  • negative regulation of gene expression, epigenetic
  • negative regulation of transcription, DNA-templated
  • negative regulation of G0 to G1 transition
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80314

13831

Ensembl

ENSG00000120616

ENSMUSG00000024240

UniProt

Q9H2F5

Q8C9X6

RefSeq (mRNA)

NM_001272004
NM_001272019
NM_001282391
NM_025209

NM_001276350
NM_007935
NM_027497

RefSeq (protein)

NP_001258933
NP_001258948
NP_001269320
NP_079485

NP_001263279
NP_031961
NP_081773

Location (UCSC)Chr 10: 32.27 – 32.38 MbChr 18: 6.44 – 6.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120616 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024240 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shimono Y, Murakami H, Hasegawa Y, Takahashi M (Jan 2001). "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions". J Biol Chem. 275 (50): 39411–9. doi:10.1074/jbc.M006585200. PMID 10976108.
  6. ^ "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)".

Further reading

  • Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
  • Liedtke W, Meyer G, Faustmann PM, et al. (1997). "Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients". Int. Immunol. 9 (7): 1031–41. doi:10.1093/intimm/9.7.1031. PMID 9237112.
  • Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
  • Kenny TP, Semrad TJ, Malyj W, Robbins DL (2001). "Mutational analysis of immunoglobulin germline derived Vlambda4B light chains in rheumatoid arthritis". Clin. Immunol. 99 (2): 283–90. doi:10.1006/clim.2001.5020. PMID 11318600.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Attwooll C, Oddi S, Cartwright P, et al. (2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner". J. Biol. Chem. 280 (2): 1199–208. doi:10.1074/jbc.M412509200. PMID 15536069.
  • Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.


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