ETV7

Protein-coding gene in the species Homo sapiens
ETV7
Identifiers
AliasesETV7, TEL-2, TEL2, TELB, ETS variant 7, ETS variant transcription factor 7
External IDsOMIM: 605255; HomoloGene: 56746; GeneCards: ETV7; OMA:ETV7 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ETV7
Genomic location for ETV7
Band6p21.31Start36,354,091 bp[1]
End36,387,800 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • triceps brachii muscle

  • glutes

  • gonad

  • olfactory bulb

  • skin of leg

  • testicle

  • beta cell

  • skin of abdomen

  • granulocyte
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • protein binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • animal organ morphogenesis
  • cell differentiation
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51513

n/a

Ensembl

ENSG00000010030

n/a

UniProt

Q9Y603

n/a

RefSeq (mRNA)
NM_001207035
NM_001207036
NM_001207037
NM_001207038
NM_001207039

NM_001207040
NM_001207041
NM_016135

n/a

RefSeq (protein)
NP_001193964
NP_001193965
NP_001193966
NP_001193967
NP_001193968

NP_001193969
NP_001193970
NP_057219

n/a

Location (UCSC)Chr 6: 36.35 – 36.39 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Transcription factor ETV7 is a protein that in humans is encoded by the ETV7 gene.[3][4][5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010030 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Potter MD, Buijs A, Kreider B, van Rompaey L, Grosveld GC (Jun 2000). "Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6". Blood. 95 (11): 3341–8. doi:10.1182/blood.V95.11.3341. PMID 10828014.
  4. ^ Gu X, Shin BH, Akbarali Y, Weiss A, Boltax J, Oettgen P, Libermann TA (Mar 2001). "Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6". J Biol Chem. 276 (12): 9421–36. doi:10.1074/jbc.M010070200. PMID 11108721.
  5. ^ "Entrez Gene: ETV7 ets variant gene 7 (TEL2 oncogene)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Poirel H, Lopez RG, Lacronique V, et al. (2000). "Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL". Oncogene. 19 (41): 4802–6. doi:10.1038/sj.onc.1203830. PMID 11032031. S2CID 38411496.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Cardone M, Kandilci A, Carella C, et al. (2005). "The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis". Mol. Cell. Biol. 25 (6): 2395–405. doi:10.1128/MCB.25.6.2395-2405.2005. PMC 1061619. PMID 15743832.
  • Drosophila anterior open - The Interactive Fly


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