EVI5

Protein-coding gene in the species Homo sapiens
EVI5
Identifiers
AliasesEVI5, NB4S, EVI-5, ecotropic viral integration site 5
External IDsOMIM: 602942; MGI: 104736; HomoloGene: 121902; GeneCards: EVI5; OMA:EVI5 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for EVI5
Genomic location for EVI5
Band1p22.1Start92,508,696 bp[1]
End92,792,404 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for EVI5
Genomic location for EVI5
Band5 F|5 52.23 cMStart107,892,661 bp[2]
End108,022,973 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • sural nerve

  • tendon of biceps brachii

  • Epithelium of choroid plexus

  • skin of hip

  • testicle

  • seminal vesicula

  • parietal pleura

  • corpus callosum

  • visceral pleura
Top expressed in
  • zygote

  • sciatic nerve

  • secondary oocyte

  • epithelium of lens

  • Rostral migratory stream

  • saccule

  • facial motor nucleus

  • primary oocyte

  • left lobe of liver

  • cumulus cell
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GTPase activator activity
Cellular component
  • cytoplasm
  • cytosol
  • spindle
  • cytoskeleton
  • nucleus
  • microtubule organizing center
  • endomembrane system
  • Golgi apparatus
  • intracellular membrane-bounded organelle
Biological process
  • cell division
  • multicellular organism development
  • regulation of cilium assembly
  • regulation of GTPase activity
  • cell cycle
  • cell population proliferation
  • retrograde transport, endosome to Golgi
  • regulation of vesicle fusion
  • intracellular protein transport
  • activation of GTPase activity
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7813

14020

Ensembl

ENSG00000067208

ENSMUSG00000011831

UniProt

O60447

P97366

RefSeq (mRNA)
NM_001308248
NM_005665
NM_001350197
NM_001350198
NM_001377210

NM_001377211
NM_001377212
NM_001377213

NM_007964
NM_001378824
NM_001378825

RefSeq (protein)
NP_001295177
NP_005656
NP_001337126
NP_001337127
NP_001364139

NP_001364140
NP_001364141
NP_001364142

n/a

Location (UCSC)Chr 1: 92.51 – 92.79 MbChr 5: 107.89 – 108.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ecotropic viral integration site 5 protein homolog is a protein that in humans is encoded by the EVI5 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067208 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011831 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roberts T, Chernova O, Cowell JK (Jul 1998). "NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma". Human Molecular Genetics. 7 (7): 1169–78. doi:10.1093/hmg/7.7.1169. PMID 9618176.
  6. ^ "Entrez Gene: EVI5 ecotropic viral integration site 5".

Further reading

  • Dabbeekeh JT, Faitar SL, Dufresne CP, Cowell JK (Apr 2007). "The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11". Oncogene. 26 (19): 2804–8. doi:10.1038/sj.onc.1210081. PMID 17099728.
  • Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG (Jan 2007). "Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1236–41. Bibcode:2007PNAS..104.1236W. doi:10.1073/pnas.0610500104. PMC 1773056. PMID 17229837.
  • Faitar SL, Sossey-Alaoui K, Ranalli TA, Cowell JK (Jul 2006). "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis". Experimental Cell Research. 312 (12): 2325–35. doi:10.1016/j.yexcr.2006.03.032. PMID 16764853.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (Jan 2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210. S2CID 15578836.
  • Faitar SL, Dabbeekeh JT, Ranalli TA, Cowell JK (Nov 2005). "EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin". Genomics. 86 (5): 594–605. doi:10.1016/j.ygeno.2005.06.002. PMID 16033705.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.


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