EXOC8

Protein-coding gene in the species Homo sapiens

EXOC8

Identifiers

Aliases

EXOC8, EXO84, Exo84p, SEC84, exocyst complex component 8, NEDMISB

External IDs

OMIM: 615283; MGI: 2142527; HomoloGene: 44545; GeneCards: EXOC8; OMA:EXOC8 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q42.2	Start	231,332,753 bp^[1]
Band	1q42.2	End	231,337,852 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E2	Start	125,619,847 bp^[2]
Band	8\|8 E2	End	125,624,444 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic epithelial cell

deltoid muscle

endothelial cell

germinal epithelium

parietal pleura

skin of thigh

Brodmann area 23

visceral pleura

amniotic fluid

tibialis anterior muscle

Top expressed in

spermatocyte

pineal gland

parotid gland

epithelium of stomach

lacrimal gland

brown adipose tissue

conjunctival fornix

stroma of bone marrow

seminal vesicula

ciliary body

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	late endosome cell projection membrane growth cone plasma membrane exocyst cytoplasm cytosol perinuclear region of cytoplasm cell leading edge
Biological process	extracellular matrix disassembly endosome organization exocyst localization exocyst assembly protein transport regulation of macroautophagy exocytosis transport Golgi to plasma membrane transport protein localization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


149371


102058

Ensembl


ENSG00000116903


ENSMUSG00000074030

UniProt


Q8IYI6


Q6PGF7

RefSeq (mRNA)


NM_175876


NM_198103

RefSeq (protein)


NP_787072


NP_932771

Location (UCSC)

Chr 1: 231.33 – 231.34 Mb

Chr 8: 125.62 – 125.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Exocyst complex component 8 is a protein that in humans is encoded by the EXOC8 gene.^[5]^[6]

Interactions

EXOC8 has been shown to interact with RALB.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074030 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: EXOC8 exocyst complex component 8".
^ Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.

Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. Bibcode:1997PNAS...9414438K. doi:10.1073/pnas.94.26.14438. PMC 25013. PMID 9405631.
Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron. 20 (6): 1111–22. doi:10.1016/S0896-6273(00)80493-6. PMID 9655500. S2CID 10915358.
Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615.
Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): 629–33. Bibcode:2003Natur.422..629I. doi:10.1038/nature01533. hdl:2027.42/62982. PMID 12687004. S2CID 4395760.
Wang S, Hsu SC (2004). "Immunological characterization of exocyst complex subunits in cell differentiation". Hybrid. Hybridomics. 22 (3): 159–64. doi:10.1089/153685903322286575. PMID 12954101.
Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

PDB gallery

1zc3: Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA
1zc4: Crystal structure of the Ral-binding domain of Exo84 in complex with the active RalA