Extended synaptotagmin-2

Protein-coding gene in the species Homo sapiens
ESYT2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DMG, 4NPJ, 4NPK, 4P42

Identifiers
AliasesESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2
External IDsOMIM: 616691; MGI: 1261845; HomoloGene: 32699; GeneCards: ESYT2; OMA:ESYT2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ESYT2
Genomic location for ESYT2
Band7q36.3Start158,730,995 bp[1]
End158,830,253 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for ESYT2
Genomic location for ESYT2
Band12 F2|12 62.65 cMStart116,244,816 bp[2]
End116,354,670 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • synovial membrane

  • Achilles tendon

  • saphenous vein

  • synovial joint

  • endothelial cell

  • urethra

  • cardiac muscle tissue of right atrium

  • myocardium of left ventricle

  • skin of arm

  • skin of hip
Top expressed in
  • interventricular septum

  • decidua

  • uterus

  • belly cord

  • ascending aorta

  • superior cervical ganglion

  • secondary oocyte

  • cervix

  • granulocyte

  • gastrula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium-dependent phospholipid binding
  • calcium ion binding
  • protein binding
  • metal ion binding
  • phosphatidylinositol binding
  • phosphatidylethanolamine binding
  • phosphatidylcholine binding
  • identical protein binding
  • lipid binding
  • cadherin binding
Cellular component
  • intrinsic component of endoplasmic reticulum membrane
  • organelle membrane contact site
  • integral component of membrane
  • extrinsic component of cytoplasmic side of plasma membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • endoplasmic reticulum-plasma membrane contact site
Biological process
  • lipid transport
  • endocytosis
  • glycosphingolipid metabolic process
  • transport
  • endoplasmic reticulum-plasma membrane tethering
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57488

52635

Ensembl

ENSG00000117868

ENSMUSG00000021171

UniProt

A0FGR8

Q3TZZ7

RefSeq (mRNA)

NM_020728

NM_028731

RefSeq (protein)

NP_065779
NP_001354702

NP_083007

Location (UCSC)Chr 7: 158.73 – 158.83 MbChr 12: 116.24 – 116.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117868 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021171 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
  6. ^ "Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  • Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
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  • 2dmg: Solution structure of the third C2 domain of KIAA1228 protein
    2dmg: Solution structure of the third C2 domain of KIAA1228 protein


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