OTULIN |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3ZNV, 3ZNX, 3ZNZ, 4KSJ, 4KSK, 4KSL, 4OYK, 4P0B |
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Identifiers |
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Aliases | OTULIN, FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS |
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External IDs | OMIM: 615712; MGI: 3577015; HomoloGene: 106591; GeneCards: OTULIN; OMA:OTULIN - orthologs |
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Gene location (Human) |
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![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
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| Band | 5p15.2 | Start | 14,664,664 bp[1] |
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End | 14,699,850 bp[1] |
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Gene location (Mouse) |
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![Chromosome 15 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_15.svg/260px-Ideogram_house_mouse_chromosome_15.svg.png) | Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15|15 B1 | Start | 27,542,721 bp[2] |
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End | 27,630,779 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - buccal mucosa cell
- bone marrow cells
- pancreatic ductal cell
- sural nerve
- skin of arm
- monocyte
- Achilles tendon
- tonsil
- skin of abdomen
- skin of leg
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| Top expressed in | - yolk sac
- otic vesicle
- left lobe of liver
- right kidney
- saccule
- spermatid
- granulocyte
- soleus muscle
- proximal tubule
- muscle of thigh
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - cysteine-type peptidase activity
- thiol-dependent deubiquitinase
- peptidase activity
- protein binding
- hydrolase activity
| Cellular component | - cytosol
- LUBAC complex
- cytoplasm
| Biological process | - immune system process
- Wnt signaling pathway
- proteolysis
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- angiogenesis
- canonical Wnt signaling pathway
- sprouting angiogenesis
- protein linear deubiquitination
- regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- negative regulation of inflammatory response
- regulation of canonical Wnt signaling pathway
- protein ubiquitination
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 5: 14.66 – 14.7 Mb | Chr 15: 27.54 – 27.63 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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