FAM105B

Protein-coding gene in the species Homo sapiens
OTULIN
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3ZNV, 3ZNX, 3ZNZ, 4KSJ, 4KSK, 4KSL, 4OYK, 4P0B

Identifiers
AliasesOTULIN, FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS
External IDsOMIM: 615712; MGI: 3577015; HomoloGene: 106591; GeneCards: OTULIN; OMA:OTULIN - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for OTULIN
Genomic location for OTULIN
Band5p15.2Start14,664,664 bp[1]
End14,699,850 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for OTULIN
Genomic location for OTULIN
Band15|15 B1Start27,542,721 bp[2]
End27,630,779 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • bone marrow cells

  • pancreatic ductal cell

  • sural nerve

  • skin of arm

  • monocyte

  • Achilles tendon

  • tonsil

  • skin of abdomen

  • skin of leg
Top expressed in
  • yolk sac

  • otic vesicle

  • left lobe of liver

  • right kidney

  • saccule

  • spermatid

  • granulocyte

  • soleus muscle

  • proximal tubule

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cysteine-type peptidase activity
  • thiol-dependent deubiquitinase
  • peptidase activity
  • protein binding
  • hydrolase activity
Cellular component
  • cytosol
  • LUBAC complex
  • cytoplasm
Biological process
  • immune system process
  • Wnt signaling pathway
  • proteolysis
  • nucleotide-binding oligomerization domain containing 2 signaling pathway
  • angiogenesis
  • canonical Wnt signaling pathway
  • sprouting angiogenesis
  • protein linear deubiquitination
  • regulation of tumor necrosis factor-mediated signaling pathway
  • negative regulation of NF-kappaB transcription factor activity
  • innate immune response
  • negative regulation of inflammatory response
  • regulation of canonical Wnt signaling pathway
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90268

432940

Ensembl

ENSG00000154124

ENSMUSG00000046034

UniProt

Q96BN8

Q3UCV8

RefSeq (mRNA)

NM_138348

NM_001013792

RefSeq (protein)

NP_612357

NP_001013814

Location (UCSC)Chr 5: 14.66 – 14.7 MbChr 15: 27.54 – 27.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Family with sequence similarity 105, member B is a protein in humans that is encoded by the FAM105B gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154124 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046034 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Family with sequence similarity 105, member B". Retrieved 2012-11-19.

Further reading


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