FBXO9

Protein-coding gene in the species Homo sapiens

FBXO9
Identifiers
AliasesFBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box protein 9
External IDsOMIM: 609091; MGI: 1918788; HomoloGene: 8217; GeneCards: FBXO9; OMA:FBXO9 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FBXO9
Genomic location for FBXO9
Band6p12.1Start53,051,991 bp[1]
End53,100,873 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for FBXO9
Genomic location for FBXO9
Band9|9 E1Start77,988,781 bp[2]
End78,016,347 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Brodmann area 23

  • middle temporal gyrus

  • right adrenal gland

  • right adrenal cortex

  • secondary oocyte

  • left adrenal gland

  • trabecular bone

  • left adrenal cortex

  • tibia
Top expressed in
  • medial vestibular nucleus

  • blood

  • ciliary body

  • retinal pigment epithelium

  • dorsal tegmental nucleus

  • pontine nuclei

  • deep cerebellar nuclei

  • motor neuron

  • medial geniculate nucleus

  • ventral tegmental area
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-protein transferase activity
Cellular component
  • cytoplasm
  • ubiquitin ligase complex
  • SCF ubiquitin ligase complex
  • cytosol
Biological process
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • innate immune response
  • regulation of TOR signaling
  • fat cell differentiation
  • protein ubiquitination
  • protein polyubiquitination
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26268

71538

Ensembl

ENSG00000112146

ENSMUSG00000001366

UniProt

Q9UK97

Q8BK06

RefSeq (mRNA)

NM_012347
NM_033480
NM_033481

NM_001081490
NM_023605

RefSeq (protein)

NP_036479
NP_258441
NP_258442

NP_001074959
NP_076094

Location (UCSC)Chr 6: 53.05 – 53.1 MbChr 9: 77.99 – 78.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112146 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001366 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. ^ a b "Entrez Gene: FBXO9 F-box protein 9".

Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.


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