FCRL1

Protein-coding gene in the species Homo sapiens
FCRL1
Identifiers
AliasesFCRL1, CD307a, FCRH1, IFGP1, IRTA5, Fc receptor like 1
External IDsOMIM: 606508; MGI: 2442862; HomoloGene: 50472; GeneCards: FCRL1; OMA:FCRL1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FCRL1
Genomic location for FCRL1
Band1q23.1Start157,794,403 bp[1]
End157,820,120 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for FCRL1
Genomic location for FCRL1
Band3|3 F1Start87,283,694 bp[2]
End87,310,241 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • appendix

  • spleen

  • lymph node

  • granulocyte

  • buccal mucosa cell

  • bone marrow cells

  • blood

  • epithelium of nasopharynx

  • mucosa of ileum

  • tonsil
Top expressed in
  • spleen

  • mesenteric lymph nodes

  • blood

  • granulocyte

  • subcutaneous adipose tissue

  • embryo

  • bone marrow

  • thymus

  • Paneth cell

  • yolk sac
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • coreceptor activity
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
  • cell surface
Biological process
  • signal transduction
  • B cell activation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115350

229499

Ensembl

ENSG00000163534

ENSMUSG00000059994

UniProt

Q96LA6

Q8R4Y0

RefSeq (mRNA)

NM_001159397
NM_001159398
NM_052938

NM_001136236
NM_153090
NM_178165
NM_001310545

RefSeq (protein)

NP_001152869
NP_001152870
NP_443170

NP_001129708
NP_001297474
NP_694730
NP_835459

Location (UCSC)Chr 1: 157.79 – 157.82 MbChr 3: 87.28 – 87.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fc receptor-like protein 1 is a protein that in humans is encoded by the FCRL1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163534 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059994 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–9777. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
  6. ^ Miller I, Hatzivassiliou G, Cattoretti G, Mendelsohn C, Dalla-Favera R (Apr 2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–2669. doi:10.1182/blood.V99.8.2662. PMID 11929751.
  7. ^ "Entrez Gene: FCRL1 Fc receptor-like 1".

Further reading

  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–328. doi:10.1007/s00251-007-0195-9. PMID 17273841. S2CID 1971426.
  • Leu CM, Davis RS, Gartland LA, et al. (2005). "FcRH1: an activation coreceptor on human B cells". Blood. 105 (3): 1121–1126. doi:10.1182/blood-2004-06-2344. PMID 15479727.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics. 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601. S2CID 9452957.
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