Protein-coding gene in the species Homo sapiens
| FLOT1 |
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| Identifiers |
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| Aliases | FLOT1, flotillin 1 |
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| External IDs | OMIM: 606998; MGI: 1100500; HomoloGene: 31337; GeneCards: FLOT1; OMA:FLOT1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6p21.33 | Start | 30,727,709 bp[1] |
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| End | 30,742,732 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 17 (mouse)[2] |
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| | Band | 17|17 B1 | Start | 36,134,122 bp[2] |
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| End | 36,143,683 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right adrenal gland
- left adrenal gland
- left adrenal cortex
- right adrenal cortex
- apex of heart
- blood
- C1 segment
- dorsolateral prefrontal cortex
- left ventricle
- cerebellum
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| | Top expressed in | - granulocyte
- interventricular septum
- cardiac muscle tissue of left ventricle
- right ventricle
- dentate gyrus of hippocampal formation granule cell
- ankle joint
- sciatic nerve
- facial motor nucleus
- spinal ganglia
- visual cortex
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - protease binding
- protein binding
- protein heterodimerization activity
- ionotropic glutamate receptor binding
| | Cellular component | - integral component of membrane
- endosome
- membrane
- cell-cell contact zone
- focal adhesion
- plasma membrane raft
- melanosome
- plasma membrane
- centriolar satellite
- microtubule organizing center
- lysosomal membrane
- flotillin complex
- uropod
- basolateral plasma membrane
- early endosome
- apical plasma membrane
- cortical actin cytoskeleton
- caveola
- membrane raft
- COP9 signalosome
- sarcolemma
- extracellular exosome
- cytoplasmic vesicle
- lamellipodium
- cell-cell junction
- external side of plasma membrane
- synapse
- presynaptic active zone
- dopaminergic synapse
- presynapse
- glutamatergic synapse
- GABA-ergic synapse
| | Biological process | - positive regulation of cell-cell adhesion mediated by cadherin
- positive regulation of cell adhesion molecule production
- positive regulation of protein phosphorylation
- regulation of toll-like receptor 4 signaling pathway
- positive regulation of heterotypic cell-cell adhesion
- positive regulation of toll-like receptor 3 signaling pathway
- axonogenesis
- positive regulation of skeletal muscle tissue development
- positive regulation of cytokine production
- extracellular matrix disassembly
- protein kinase C signaling
- response to endoplasmic reticulum stress
- positive regulation of myoblast fusion
- positive regulation of endocytosis
- positive regulation of cell junction assembly
- protein localization to membrane raft
- membrane raft assembly
- cellular response to exogenous dsRNA
- regulation of receptor internalization
- positive regulation of synaptic transmission, dopaminergic
- positive regulation of protein binding
- regulation of Rho protein signal transduction
- protein homooligomerization
- dsRNA transport
- plasma membrane raft assembly
- positive regulation of interferon-beta production
- protein stabilization
- protein localization to plasma membrane
- regulation of neurotransmitter uptake
- positive regulation of NF-kappaB transcription factor activity
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | ENSG00000137312
ENSG00000232280
ENSG00000224740
ENSG00000206480
ENSG00000206379
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ENSG00000230143
ENSG00000236271
ENSG00000223654 |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 30.73 – 30.74 Mb | Chr 17: 36.13 – 36.14 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[5]
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[6] The function of flotillin 1 has not been determined.[5]
Interactions
FLOT1 has been shown to interact with SORBS1.[7][8][9]
References
- ^ a b c ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059714 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: FLOT1 flotillin 1".
- ^ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
- ^ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. S2CID 14083271.
- ^ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.
- ^ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe". J. Biol. Chem. 274 (18): 12702–9. doi:10.1074/jbc.274.18.12702. PMID 10212252.
- Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation". J. Cell. Biochem. 75 (1): 147–59. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D. PMID 10462713. S2CID 12223151.
- Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
- Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl:2027.42/62940. PMID 11001060. S2CID 4334519.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts". Blood. 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID 11159550.
- Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals". Int. J. Biochem. Cell Biol. 33 (1): 53–64. doi:10.1016/S1357-2725(00)00069-8. PMID 11167132.
- Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.
- Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2". Mol. Biol. Cell. 12 (10): 3031–45. doi:10.1091/mbc.12.10.3031. PMC 60153. PMID 11598189.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. doi:10.1051/jbio/2003197030223. PMID 14708344. S2CID 86221484.
- Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID 15120622.
- Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873. S2CID 14083271.
- Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Mol. Biol. Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain". Neurotoxicity Research. 6 (4): 245–57. doi:10.1007/BF03033435. PMID 15545008. S2CID 22168131.
- Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
- Glebov OO, Bright NA, Nichols BJ (2006). "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells". Nat. Cell Biol. 8 (1): 46–54. doi:10.1038/ncb1342. PMID 16341206. S2CID 36695735.
External links
