FSCN3

Protein-coding gene in the species Homo sapiens
FSCN3
Identifiers
AliasesFSCN3, fascin actin-bundling protein 3
External IDsOMIM: 615800; MGI: 1890386; HomoloGene: 10475; GeneCards: FSCN3; OMA:FSCN3 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for FSCN3
Genomic location for FSCN3
Band7q32.1Start127,591,409 bp[1]
End127,602,144 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for FSCN3
Genomic location for FSCN3
Band6|6 A3.3Start28,427,788 bp[2]
End28,438,621 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • left testis

  • right testis

  • testicle

  • granulocyte

  • gonad

  • muscle of thigh

  • cerebellar cortex

  • cerebellar hemisphere

  • prefrontal cortex
Top expressed in
  • seminiferous tubule

  • spermatid

  • blastocyst

  • embryo

  • spermatocyte

  • embryo

  • upper arm

  • medial ganglionic eminence

  • triceps brachii muscle

  • yolk sac
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein-macromolecule adaptor activity
  • actin binding
  • actin filament binding
Cellular component
  • cytoskeleton
  • actin cytoskeleton
  • cytoplasm
  • filamentous actin
  • ruffle
  • microvillus
  • lamellipodium
  • filopodium
  • growth cone
  • cell projection membrane
Biological process
  • spermatid development
  • actin filament organization
  • anatomical structure morphogenesis
  • establishment or maintenance of cell polarity
  • actin filament bundle assembly
  • cell migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29999

56223

Ensembl

ENSG00000106328

ENSMUSG00000029707

UniProt

Q9NQT6

Q9QXW4

RefSeq (mRNA)

NM_020369

NM_019569

RefSeq (protein)

NP_065102

NP_062515

Location (UCSC)Chr 7: 127.59 – 127.6 MbChr 6: 28.43 – 28.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fascin-3 also known as testis fascin is a protein that in humans is encoded by the FSCN3 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106328 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: fascin homolog 3".
  6. ^ Tubb B, Mulholland DJ, Vogl W, Lan ZJ, Niederberger C, Cooney A, Bryan J (April 2002). "Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head". Exp. Cell Res. 275 (1): 92–109. doi:10.1006/excr.2002.5486. PMID 11925108.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Tubb BE, Bardien-Kruger S, Kashork CD, et al. (2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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