GAS2

Protein-coding gene in the species Homo sapiens
GAS2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1V5R

Identifiers
AliasesGAS2, growth arrest specific 2, GAS-2
External IDsOMIM: 602835; MGI: 95657; HomoloGene: 31301; GeneCards: GAS2; OMA:GAS2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for GAS2
Genomic location for GAS2
Band11p14.3Start22,625,509 bp[1]
End22,813,001 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for GAS2
Genomic location for GAS2
Band7 B4|7 32.87 cMStart51,511,763 bp[2]
End51,644,723 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trigeminal ganglion

  • liver

  • sural nerve

  • right lobe of liver

  • islet of Langerhans

  • C1 segment

  • Skeletal muscle tissue of rectus abdominis

  • Achilles tendon

  • gonad

  • spinal ganglia
Top expressed in
  • vestibular sensory epithelium

  • stria vascularis

  • vestibular membrane of cochlear duct

  • right kidney

  • proximal tubule

  • utricle

  • human kidney

  • hand

  • cochlea

  • saccule
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule binding
  • actin binding
Cellular component
  • cytoskeleton
  • cytosol
  • actin filament
  • membrane
  • cytoplasm
Biological process
  • cell cycle
  • regulation of cell shape
  • apoptotic process
  • initiation of primordial ovarian follicle growth
  • antral ovarian follicle growth
  • regulation of Notch signaling pathway
  • ovulation
  • basement membrane organization
  • microtubule cytoskeleton organization
  • actin cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2620

14453

Ensembl

ENSG00000148935

ENSMUSG00000030498

UniProt

O43903

P11862

RefSeq (mRNA)
NM_001143830
NM_005256
NM_177553
NM_001351224
NM_001391933

NM_001391934
NM_001391935
NM_001391936
NM_001391937

NM_008087
NM_001330607
NM_001330608

RefSeq (protein)

NP_001137302
NP_005247
NP_808221
NP_001338153

NP_001317536
NP_001317537
NP_032113

Location (UCSC)Chr 11: 22.63 – 22.81 MbChr 7: 51.51 – 51.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.[5][6]

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148935 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030498 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
  6. ^ a b "Entrez Gene: GAS2 growth arrest-specific 2".

Further reading

  • Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of Oral Surgery. 33 (8): 619–21. PMID 1056466.
  • Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
  • Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell. 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319. S2CID 37196421.
  • Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell Sci. 112 (23): 4475–82. doi:10.1242/jcs.112.23.4475. PMID 10564664.
  • Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501. PMID 11387205.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi:10.1074/jbc.M501810200. PMID 15817486.
  • v
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  • 1v5r: Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein
    1v5r: Solution Structure of the Gas2 Domain of the Growth Arrest Specific 2 Protein


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