GBF1

Protein-coding gene in the species Homo sapiens

GBF1
Identifiers
AliasesGBF1, ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1, CMT2GG
External IDsOMIM: 603698; MGI: 1861607; HomoloGene: 37897; GeneCards: GBF1; OMA:GBF1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GBF1
Genomic location for GBF1
Band10q24.32Start102,245,371 bp[1]
End102,382,899 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for GBF1
Genomic location for GBF1
Band19|19 C3Start46,140,948 bp[2]
End46,274,949 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • ventricular zone

  • anterior pituitary

  • sural nerve

  • stromal cell of endometrium

  • ganglionic eminence

  • right lobe of thyroid gland

  • apex of heart

  • mucosa of transverse colon

  • right hemisphere of cerebellum
Top expressed in
  • neural layer of retina

  • zygote

  • tail of embryo

  • lacrimal gland

  • secondary oocyte

  • genital tubercle

  • muscle of thigh

  • seminiferous tubule

  • molar

  • parotid gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-3,5-bisphosphate binding
  • protein binding
  • guanyl-nucleotide exchange factor activity
  • phosphatidylinositol-3,4,5-trisphosphate binding
  • lipid binding
Cellular component
  • lipid droplet
  • Golgi membrane
  • trans-Golgi network
  • cell leading edge
  • peroxisome
  • cytoplasm
  • endoplasmic reticulum lumen
  • Golgi stack
  • mitochondrion
  • cytosol
  • Golgi apparatus
  • membrane
  • cis-Golgi network
  • endoplasmic reticulum-Golgi intermediate compartment
Biological process
  • Golgi disassembly
  • protein localization to endoplasmic reticulum tubular network
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • protein transport
  • Golgi organization
  • viral process
  • regulation of mitotic cell cycle
  • endoplasmic reticulum-Golgi intermediate compartment organization
  • post-Golgi vesicle-mediated transport
  • establishment of monopolar cell polarity
  • protein localization to endoplasmic reticulum exit site
  • regulation of protein localization to cell surface
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • cell activation involved in immune response
  • protein localization to Golgi apparatus
  • neutrophil chemotaxis
  • reactive oxygen species biosynthetic process
  • retrograde transport, endosome to Golgi
  • Golgi to endosome transport
  • regulation of ARF protein signal transduction
  • COPI coating of Golgi vesicle
  • transport
  • regulation of molecular function
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8729

107338

Ensembl

ENSG00000107862

ENSMUSG00000025224

UniProt

Q92538

n/a

RefSeq (mRNA)
NM_001199378
NM_001199379
NM_004193
NM_001377137
NM_001377138

NM_001377139
NM_001377140
NM_001377141
NM_001391922
NM_001391923
NM_001391924
NM_001391925
NM_001391926
NM_001391927
NM_001391928
NM_001391929
NM_001391930
NM_001391931

NM_178930

RefSeq (protein)

NP_001186307
NP_001186308
NP_004184

n/a

Location (UCSC)Chr 10: 102.25 – 102.38 MbChr 19: 46.14 – 46.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107862 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025224 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.
  6. ^ "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Claude A, Zhao BP, Kuziemsky CE, et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5". J. Cell Biol. 146 (1): 71–84. doi:10.1083/jcb.146.1.71. PMC 2199737. PMID 10402461.
  • Kawamoto K, Yoshida Y, Tamaki H, et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat". Traffic. 3 (7): 483–95. doi:10.1034/j.1600-0854.2002.30705.x. PMID 12047556. S2CID 45336536.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890. PMID 12634853.
  • Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity". Biochem. Biophys. Res. Commun. 303 (1): 160–9. doi:10.1016/S0006-291X(03)00316-4. hdl:10533/173991. PMID 12646181.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi". Mol. Biol. Cell. 16 (3): 1213–22. doi:10.1091/mbc.E04-07-0599. PMC 551486. PMID 15616190.
  • Szul T, Garcia-Mata R, Brandon E, et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1". Traffic. 6 (5): 374–85. doi:10.1111/j.1600-0854.2005.00282.x. PMID 15813748. S2CID 23845874.
  • Roy SK, Hu J, Meng Q, et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions". J. Interferon Cytokine Res. 25 (11): 666–73. doi:10.1089/jir.2005.25.666. PMID 16318580.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Zhao X, Claude A, Chun J, et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic". J. Cell Sci. 119 (Pt 18): 3743–53. doi:10.1242/jcs.03173. PMID 16926190.
  • Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330.


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