GCC1

Protein-coding gene in the species Homo sapiens

GCC1
Identifiers
AliasesGCC1, GCC1P, GCC88, GRIP and coiled-coil domain containing 1
External IDsOMIM: 607418; MGI: 1921625; HomoloGene: 11567; GeneCards: GCC1; OMA:GCC1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GCC1
Genomic location for GCC1
Band7q32.1Start127,580,628 bp[1]
End127,593,611 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GCC1
Genomic location for GCC1
Band6|6 A3.3Start28,416,090 bp[2]
End28,428,389 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • islet of Langerhans

  • granulocyte

  • stromal cell of endometrium

  • blood

  • right testis

  • left testis

  • sperm

  • nipple

  • skin of thigh
Top expressed in
  • granulocyte

  • supraoptic nucleus

  • ascending aorta

  • spermatocyte

  • islet of Langerhans

  • aortic valve

  • stria vascularis

  • spermatid

  • jejunum

  • transitional epithelium of urinary bladder
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79571

74375

Ensembl

ENSG00000179562

ENSMUSG00000029708

UniProt

Q96CN9

Q9D4H2

RefSeq (mRNA)

NM_024523

NM_028900

RefSeq (protein)

NP_078799

NP_083176

Location (UCSC)Chr 7: 127.58 – 127.59 MbChr 6: 28.42 – 28.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.[5][6]

Function

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport.[6]

Interactions

GCC1 has been shown to interact with TRIM29.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179562 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029708 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. Bibcode:1999CBio....9..385K. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. S2CID 14342088.
  6. ^ a b "Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1".
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J. Biol. Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
  • Lu L, Hong W (2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  • Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers". Biochem. J. 388 (Pt 3): 835–41. doi:10.1042/BJ20041810. PMC 1183463. PMID 15654769.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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