GCM1

Protein-coding gene in the species Homo sapiens
GCM1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ODH

Identifiers
AliasesGCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDsOMIM: 603715; MGI: 108045; HomoloGene: 2702; GeneCards: GCM1; OMA:GCM1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GCM1
Genomic location for GCM1
Band6p12.1Start53,126,961 bp[1]
End53,148,841 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for GCM1
Genomic location for GCM1
Band9 E1|9 43.49 cMStart77,959,206 bp[2]
End77,972,906 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • placenta

  • decidua

  • testicle

  • sperm

  • blood

  • kidney tubule

  • human kidney

  • islet of Langerhans

  • white blood cell

  • metanephros
Top expressed in
  • syncytiotrophoblast

  • embryo

  • proximal tubule

  • right kidney

  • yolk sac

  • trophoblast giant cell

  • lumbar spinal ganglion

  • human kidney

  • metanephros
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity
  • zinc ion binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • transcription factor binding
  • histone deacetylase binding
  • metal ion binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • transcription regulator complex
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • anatomical structure morphogenesis
  • positive regulation of syncytium formation by plasma membrane fusion
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • multicellular organism development
  • branching involved in labyrinthine layer morphogenesis
  • astrocyte fate commitment
  • positive regulation of transcription by RNA polymerase II
  • gliogenesis
  • regulation of cell differentiation involved in embryonic placenta development
  • cell differentiation involved in embryonic placenta development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8521

14531

Ensembl

ENSG00000137270

ENSMUSG00000023333

UniProt

Q9NP62

P70348

RefSeq (mRNA)

NM_003643

NM_008103

RefSeq (protein)

NP_003634

NP_032129

Location (UCSC)Chr 6: 53.13 – 53.15 MbChr 9: 77.96 – 77.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.[5][6]

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137270 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023333 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Akiyama Y, Hosoya T, Poole AM, Hotta Y (Jan 1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals". Proc Natl Acad Sci U S A. 93 (25): 14912–6. doi:10.1073/pnas.93.25.14912. PMC 26236. PMID 8962155.
  6. ^ a b "Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)".

Further reading

  • Yamada K, Ogawa H, Honda S, et al. (1999). "A GCM motif protein is involved in placenta-specific expression of human aromatase gene". J. Biol. Chem. 274 (45): 32279–86. doi:10.1074/jbc.274.45.32279. PMID 10542267.
  • Nait-Oumesmar B, Copperman AB, Lazzarini RA (2000). "Placental expression and chromosomal localization of the human Gcm 1 gene". J. Histochem. Cytochem. 48 (7): 915–22. doi:10.1177/002215540004800704. PMID 10858268.
  • Yamada K, Ogawa H, Tamiya G, et al. (2001). "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene". Biochem. Biophys. Res. Commun. 278 (1): 134–9. doi:10.1006/bbrc.2000.3775. PMID 11071865.
  • Yu C, Shen K, Lin M, et al. (2003). "GCMa regulates the syncytin-mediated trophoblastic fusion". J. Biol. Chem. 277 (51): 50062–8. doi:10.1074/jbc.M209316200. PMID 12397062.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Chen CP, Chen CY, Yang YC, et al. (2005). "Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia". Placenta. 25 (5): 413–21. doi:10.1016/j.placenta.2003.10.014. PMID 15081636.
  • Baczyk D, Satkunaratnam A, Nait-Oumesmar B, et al. (2004). "Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta". Placenta. 25 (6): 553–9. doi:10.1016/j.placenta.2003.12.004. PMID 15135239.
  • Schubert SW, Kardash E, Khan MA, et al. (2005). "Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2". J. Biol. Chem. 279 (48): 50358–65. doi:10.1074/jbc.M404587200. PMID 15385555.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yang CS, Yu C, Chuang HC, et al. (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526.
  • Knerr I, Schubert SW, Wich C, et al. (2005). "Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions". FEBS Lett. 579 (18): 3991–8. doi:10.1016/j.febslet.2005.06.029. PMID 16004993. S2CID 46648257.
  • Chang CW, Chuang HC, Yu C, et al. (2005). "Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa". Mol. Cell. Biol. 25 (19): 8401–14. doi:10.1128/MCB.25.19.8401-8414.2005. PMC 1265739. PMID 16166624.
  • Chuang HC, Chang CW, Chang GD, et al. (2006). "Histone deacetylase 3 binds to and regulates the GCMa transcription factor". Nucleic Acids Res. 34 (5): 1459–69. doi:10.1093/nar/gkl048. PMC 1401512. PMID 16528103.
  • Fujito N, Samura O, Miharu N, et al. (2007). "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia". Hiroshima J. Med. Sci. 55 (1): 9–15. PMID 16594548.
  • Chou CC, Chang C, Liu JH, et al. (2007). "Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a." J. Biol. Chem. 282 (37): 27239–49. doi:10.1074/jbc.M700351200. PMID 17646165.
  • v
  • t
  • e
  • 1odh: STRUCTURE OF THE GCM DOMAIN BOUND TO DNA
    1odh: STRUCTURE OF THE GCM DOMAIN BOUND TO DNA


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e