GDI2

Protein-coding gene in the species Homo sapiens

GDI2

Identifiers

Aliases

GDI2, HEL-S-46e, RABGDIB, GDP dissociation inhibitor 2

External IDs

OMIM: 600767; MGI: 99845; HomoloGene: 37488; GeneCards: GDI2; OMA:GDI2 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p15.1	Start	5,765,223 bp^[1]
Band	10p15.1	End	5,842,132 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 A1	Start	3,588,063 bp^[2]
Band	13\|13 A1	End	3,617,871 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of ileum

mucosa of sigmoid colon

corpus epididymis

trabecular bone

visceral pleura

parietal pleura

secondary oocyte

epithelium of nasopharynx

oral cavity

Top expressed in

saccule

otic placode

renal corpuscle

mandibular prominence

maxillary prominence

otic vesicle

condyle

fossa

medullary collecting duct

internal carotid artery

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	Rab GDP-dissociation inhibitor activity GTPase activator activity small GTPase binding protein binding GDP-dissociation inhibitor activity RNA binding
Cellular component	cytoplasm vesicle cytosol membrane focal adhesion extracellular exosome extracellular region secretory granule lumen azurophil granule lumen Golgi apparatus synapse
Biological process	positive regulation of GTPase activity protein transport regulation of catalytic activity regulation of small GTPase mediated signal transduction vesicle-mediated transport signal transduction small GTPase mediated signal transduction neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2665


14569

Ensembl


ENSG00000057608


ENSMUSG00000021218

UniProt


P50395 Q5SX91


Q61598

RefSeq (mRNA)


NM_001494 NM_001115156


NM_008112

RefSeq (protein)


NP_001108628 NP_001485


NP_032138

Location (UCSC)

Chr 10: 5.77 – 5.84 Mb

Chr 13: 3.59 – 3.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.^[5]^[6]

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000057608 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021218 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sedlacek Z, Munstermann E, Mincheva A, Lichter P, Poustka A (Feb 1998). "The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13". Mamm Genome. 9 (1): 78–80. doi:10.1007/s003359900685. PMID 9434952. S2CID 36441100.
^ ^a ^b "Entrez Gene: GDI2 GDP dissociation inhibitor 2".

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Sun ZL, Zhu Y, Wang FQ, et al. (2007). "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers". Biochim. Biophys. Acta. 1774 (6): 764–71. doi:10.1016/j.bbapap.2007.04.001. PMID 17507299.