GFI1B

Protein-coding gene in the species Homo sapiens
GFI1B
Identifiers
AliasesGFI1B, BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor
External IDsOMIM: 604383; MGI: 1276578; HomoloGene: 31223; GeneCards: GFI1B; OMA:GFI1B - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GFI1B
Genomic location for GFI1B
Band9q34.13Start132,944,000 bp[1]
End132,991,687 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GFI1B
Genomic location for GFI1B
Band2|2 A3Start28,499,462 bp[2]
End28,511,994 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • trabecular bone

  • monocyte

  • bone marrow

  • blood

  • left testis

  • right testis

  • granulocyte

  • testicle

  • bone marrow cells
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • embryo

  • tibiofemoral joint

  • yolk sac

  • spleen

  • blood

  • tail of embryo

  • bone marrow

  • zygote

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nuclear matrix
  • nucleus
  • transcription regulator complex
Biological process
  • multicellular organism development
  • cell population proliferation
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • chromatin organization
  • negative regulation of G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8328

14582

Ensembl

ENSG00000165702

ENSMUSG00000026815

UniProt

Q5VTD9

O70237

RefSeq (mRNA)

NM_001135031
NM_004188
NM_001371908
NM_001377304
NM_001377305

NM_001160406
NM_008114

RefSeq (protein)

NP_001128503
NP_004179
NP_001358837
NP_001364233
NP_001364234

NP_001153878
NP_032140

Location (UCSC)Chr 9: 132.94 – 132.99 MbChr 2: 28.5 – 28.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165702 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026815 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics. 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
  6. ^ "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

  • Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): 2462–73. doi:10.1128/mcb.18.5.2462. PMC 110626. PMID 9566867.
  • Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood. 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
  • Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells". Blood. 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
  • Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas". Blood. 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
  • Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.
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