GFRAL

Protein-coding gene in the species Homo sapiens
GFRAL
Identifiers
AliasesGFRAL, C6orf144, GRAL, UNQ9356, bA360D14.1, GDNF family receptor alpha like
External IDsOMIM: 617837; MGI: 3607786; HomoloGene: 45748; GeneCards: GFRAL; OMA:GFRAL - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GFRAL
Genomic location for GFRAL
Band6p12.1Start55,327,469 bp[1]
End55,402,493 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for GFRAL
Genomic location for GFRAL
Band9|9 DStart76,071,384 bp[2]
End76,120,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • sural nerve

  • right lobe of liver

  • subcutaneous adipose tissue

  • body of pancreas

  • lactiferous gland
Top expressed in
  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signaling receptor activity
  • protein binding
  • glial cell-derived neurotrophic factor receptor activity
  • receptor tyrosine kinase binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • intracellular anatomical structure
  • membrane
  • external side of plasma membrane
  • receptor complex
Biological process
  • negative regulation of neuron apoptotic process
  • stress-activated protein kinase signaling cascade
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • reduction of food intake in response to dietary excess
  • glial cell-derived neurotrophic factor receptor signaling pathway
  • positive regulation of MAPK cascade
  • positive regulation of protein kinase B signaling
  • nervous system development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

389400

404194

Ensembl

ENSG00000187871

ENSMUSG00000059383

UniProt

Q6UXV0

Q6SJE0

RefSeq (mRNA)

NM_207410

NM_205844

RefSeq (protein)

NP_997293

NP_995316

Location (UCSC)Chr 6: 55.33 – 55.4 MbChr 9: 76.07 – 76.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GDNF family receptor alpha like is a protein that in humans is encoded by the GFRAL gene. [5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187871 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059383 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GDNF family receptor alpha like". Retrieved 2017-09-04.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q6UXV0 (GDNF family receptor alpha-like) at the PDBe-KB.


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