HABP4

Protein-coding gene in the species Homo sapiens
HABP4
Identifiers
AliasesHABP4, IHABP-4, IKi-1/57, SERBP1L, hyaluronan binding protein 4
External IDsOMIM: 617369; MGI: 1891713; HomoloGene: 8615; GeneCards: HABP4; OMA:HABP4 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for HABP4
Genomic location for HABP4
Band9q22.32Start96,450,169 bp[1]
End96,491,336 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for HABP4
Genomic location for HABP4
Band13 B3|13 33.26 cMStart64,309,638 bp[2]
End64,334,351 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • nucleus accumbens

  • olfactory bulb

  • beta cell

  • putamen

  • right frontal lobe

  • caudate nucleus

  • cingulate gyrus

  • amygdala

  • anterior cingulate cortex
Top expressed in
  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • central gray substance of midbrain

  • seminiferous tubule

  • medial vestibular nucleus

  • dorsal tegmental nucleus

  • neural layer of retina

  • right kidney

  • deep cerebellar nuclei
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
  • SUMO binding
Cellular component
  • extracellular region
  • sarcomere
  • nucleus
  • cytoplasm
  • nucleolus
  • Cajal body
  • sarcoplasm
  • nuclear body
  • nuclear speck
  • gemini of coiled bodies
  • cytosol
  • cytoplasmic stress granule
Biological process
  • negative regulation of DNA binding
  • cellular response to mechanical stimulus
  • platelet degranulation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of RNA splicing
  • positive regulation of translational initiation
  • mRNA processing
  • regulation of translation
  • RNA splicing
  • PML body organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22927

56541

Ensembl

ENSG00000130956

ENSMUSG00000021476

UniProt

Q5JVS0

Q9JKS5

RefSeq (mRNA)

NM_014282

NM_019986

RefSeq (protein)

NP_055097

NP_064370

Location (UCSC)Chr 9: 96.45 – 96.49 MbChr 13: 64.31 – 64.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intracellular hyaluronan-binding protein 4 is a protein that in humans is encoded by the HABP4 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130956 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021476 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kobarg J, Schnittger S, Fonatsch C, Lemke H, Bowen MA, Buck F, Hansen HP (May 1998). "Characterization, mapping and partial cDNA sequence of the 57-kD intracellular Ki-1 antigen". Exp Clin Immunogenet. 14 (4): 273–80. PMID 9523163.
  6. ^ Huang L, Grammatikakis N, Yoneda M, Banerjee SD, Toole BP (Nov 2000). "Molecular characterization of a novel intracellular hyaluronan-binding protein". J Biol Chem. 275 (38): 29829–39. doi:10.1074/jbc.M002737200. PMID 10887182.
  7. ^ "Entrez Gene: HABP4 hyaluronan binding protein 4".

Further reading

  • Rohde D, Hansen H, Hafner M, et al. (1992). "Cellular localizations and processing of the two molecular forms of the Hodgkin-associated Ki-1 (CD30) antigen. The protein kinase Ki-1/57 occurs in the nucleus". Am. J. Pathol. 140 (2): 473–82. PMC 1886443. PMID 1310832.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lemos TA, Passos DO, Nery FC, Kobarg J (2003). "Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3". FEBS Lett. 533 (1–3): 14–20. doi:10.1016/S0014-5793(02)03737-7. PMID 12505151. S2CID 41197943.
  • Nery FC, Passos DO, Garcia VS, Kobarg J (2004). "Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C". J. Biol. Chem. 279 (12): 11444–55. doi:10.1074/jbc.M306672200. PMID 14699138.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kobarg CB, Kobarg J, Crosara-Alberto DP, et al. (2005). "MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57". FEBS Lett. 579 (12): 2615–22. doi:10.1016/j.febslet.2005.03.078. PMID 15862299. S2CID 26654365.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Nery FC, Rui E, Kuniyoshi TM, Kobarg J (2006). "Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins". Biochem. Biophys. Res. Commun. 341 (3): 847–55. doi:10.1016/j.bbrc.2006.01.036. PMID 16455055.
  • Passos DO, Bressan GC, Nery FC, Kobarg J (2006). "Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation". FEBS J. 273 (17): 3946–61. doi:10.1111/j.1742-4658.2006.05399.x. PMID 16879614. S2CID 25895297.


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