Protein-coding gene in the species Homo sapiens
HEPN1 |
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Identifiers |
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Aliases | HEPN1, hepatocellular carcinoma, down-regulated 1 |
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External IDs | OMIM: 611641; HomoloGene: 134601; GeneCards: HEPN1; OMA:HEPN1 - orthologs |
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Gene location (Human) |
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![Chromosome 11 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png) | Chr. | Chromosome 11 (human)[1] |
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| Band | 11q24.2 | Start | 124,919,244 bp[1] |
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End | 124,920,677 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- amygdala
- putamen
- C1 segment
- substantia nigra
- caudate nucleus
- hippocampus proper
- nucleus accumbens
- right frontal lobe
- hypothalamus
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| | More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 124.92 – 124.92 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [3]
Function
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.[4] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000221932 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.
- ^ Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID 12971969.
- ^ Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID 15885354.
Further reading
- Kim HS, Jung G (2014). "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor". FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679. S2CID 859229.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.