HEPN1

Protein-coding gene in the species Homo sapiens
HEPN1
Identifiers
AliasesHEPN1, hepatocellular carcinoma, down-regulated 1
External IDsOMIM: 611641; HomoloGene: 134601; GeneCards: HEPN1; OMA:HEPN1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for HEPN1
Genomic location for HEPN1
Band11q24.2Start124,919,244 bp[1]
End124,920,677 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • amygdala

  • putamen

  • C1 segment

  • substantia nigra

  • caudate nucleus

  • hippocampus proper

  • nucleus accumbens

  • right frontal lobe

  • hypothalamus
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

641654

n/a

Ensembl

ENSG00000221932

n/a

UniProt

Q6WQI6

n/a

RefSeq (mRNA)

NM_001037558

n/a

RefSeq (protein)

NP_001032647

n/a

Location (UCSC)Chr 11: 124.92 – 124.92 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [3]

Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes.[4] Also to note is that this gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000221932 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Hepatocellular carcinoma, down-regulated 1". Retrieved 2017-09-12.
  4. ^ Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID 12971969.
  5. ^ Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID 15885354.

Further reading

  • Kim HS, Jung G (2014). "Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor". FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679. S2CID 859229.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e