HERC5

Protein-coding gene in the species Homo sapiens

HERC5

Identifiers

Aliases

HERC5, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5

External IDs

OMIM: 608242; HomoloGene: 81848; GeneCards: HERC5; OMA:HERC5 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q22.1	Start	88,457,119 bp^[1]
Band	4q22.1	End	88,506,163 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

testicle

right testis

sperm

left testis

germinal epithelium

monocyte

palpebral conjunctiva

body of uterus

left ovary

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ISG15 transferase activity protein binding transferase activity RNA binding ubiquitin-protein transferase activity ubiquitin protein ligase activity
Cellular component	perinuclear region of cytoplasm cytosol cytoplasm
Biological process	ISG15-protein conjugation negative regulation of type I interferon production regulation of cyclin-dependent protein serine/threonine kinase activity regulation of defense response to virus defense response to virus immune system process protein polyubiquitination innate immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51191


n/a

Ensembl


ENSG00000138646


n/a

UniProt


Q9UII4


n/a

RefSeq (mRNA)


NM_016323


n/a

RefSeq (protein)


NP_057407


n/a

Location (UCSC)

Chr 4: 88.46 – 88.51 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.^[3]^[4]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.^[4] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.^[5]^[6]^[7]

Interactions

HERC5 has been shown to interact with NME2^[8] and Cyclin E1.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138646 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun. 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
^ ^a ^b "Entrez Gene: HERC5 hect domain and RLD 5".
^ Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology. 8: 95. doi:10.1186/1742-4690-8-95. PMC 3228677. PMID 22093708.
^ Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol. 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.
^ Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell. 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMC 2887317. PMID 20542004.
^ Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13). Switzerland: 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMC 11131906. PMID 18535780. S2CID 6897759.