HIST1H1T

Protein-coding gene in the species Homo sapiens
H1-6
Identifiers
AliasesH1-6, H1FT, H1t, dJ221C16.2, H1.6, histone cluster 1, H1t, histone cluster 1 H1 family member t, HIST1H1T, H1.6 linker histone, cluster member
External IDsOMIM: 142712; MGI: 1888530; HomoloGene: 3889; GeneCards: H1-6; OMA:H1-6 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for H1-6
Genomic location for H1-6
Band6p22.2Start26,107,412 bp[1]
End26,108,135 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for H1-6
Genomic location for H1-6
Band13|13 A3.1Start23,879,797 bp[2]
End23,880,708 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • monocyte

  • corpus callosum

  • blood

  • left testis

  • right testis

  • islet of Langerhans

  • right lung

  • human musculoskeletal system
Top expressed in
  • spermatocyte

  • spermatid

  • embryo

  • embryo

  • pharynx

  • lesser wing of sphenoid bone

  • gray matter layer of cerebellum

  • perirhinal cortex

  • entorhinal cortex

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • double-stranded DNA binding
  • protein binding
  • nucleosomal DNA binding
Cellular component
  • nucleosome
  • nucleus
  • chromosome
  • condensed nuclear chromosome
Biological process
  • multicellular organism development
  • nucleosome assembly
  • cell differentiation
  • spermatogenesis
  • regulation of transcription, DNA-templated
  • binding of sperm to zona pellucida
  • chromosome condensation
  • flagellated sperm motility
  • negative regulation of DNA recombination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3010

107970

Ensembl

ENSG00000187475

ENSMUSG00000036211

UniProt

P22492

Q07133

RefSeq (mRNA)

NM_005323

NM_010377

RefSeq (protein)

NP_005314

NP_034507

Location (UCSC)Chr 6: 26.11 – 26.11 MbChr 13: 23.88 – 23.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.[5][6][7]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187475 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036211 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR (Jun 1994). "Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6". J Cell Biochem. 54 (2): 219–30. doi:10.1002/jcb.240540210. PMID 8175896. S2CID 13648109.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b "Entrez Gene: HIST1H1T histone cluster 1, H1t".

Further reading

  • Drabent B, Kardalinou E, Doenecke D (1991). "Structure and expression of the human gene encoding testicular H1 histone (H1t)". Gene. 103 (2): 263–8. doi:10.1016/0378-1119(91)90284-I. PMID 1889752.
  • Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
  • Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  • Malanga M, Atorino L, Tramontano F, et al. (1998). "Poly(ADP-ribose) binding properties of histone H1 variants". Biochim. Biophys. Acta. 1399 (2–3): 154–60. doi:10.1016/s0167-4781(98)00110-9. PMID 9765591.
  • Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
  • Wellman SE, Song Y, Mamoon NM (1999). "Sequence preference of mouse H1(0) and H1t". Biochemistry. 38 (40): 13112–8. doi:10.1021/bi9914917. PMID 10529182.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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