HIST1H2AD
Protein-coding gene in the species Homo sapiens
| H2AC7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | H2AC7, H2A.3, H2A/g, H2AFG, histone cluster 1, H2ad, histone cluster 1 H2A family member d, H2A clustered histone 7, HIST1H2AD | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602792; MGI: 2448306; HomoloGene: 137350; GeneCards: H2AC7; OMA:H2AC7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene.[5][6][7]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196866 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061615 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
- ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
- ^ a b "Entrez Gene: HIST1H2AD histone cluster 1, H2ad".
Further reading
- Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
- El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
- Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058. S2CID 28275496.
- Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
- Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
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PDB gallery
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1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT -
1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION -
1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE -
1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution -
1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution -
1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution -
1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA -
1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA -
1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA -
1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants -
1s32: Molecular Recognition of the Nucleosomal 'Supergroove' -
1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution -
1zbb: Structure of the 4_601_167 Tetranucleosome -
1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core -
2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione -
2cv5: Crystal structure of human nucleosome core particle -
2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes -
2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element -
2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN -
2nzd: Nucleosome core particle containing 145 bp of DNA
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