HIST1H4J

Protein-coding gene in the species Homo sapiens
H4C11
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Identifiers
AliasesH4C11, H4/e, H4F2iv, H4FE, dJ160A22.2, histone cluster 1, H4j, histone cluster 1 H4 family member j, H4 clustered histone 11, HIST1H4J, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C13, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, TEVANED2
External IDsOMIM: 602826; MGI: 2448425; HomoloGene: 134492; GeneCards: H4C11; OMA:H4C11 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for H4C11
Genomic location for H4C11
Band6p22.1Start27,824,092 bp[1]
End27,824,480 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for H4C11
Genomic location for H4C11
Band13|13 A3.1Start23,735,432 bp[2]
End23,735,822 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • testicle

  • epithelium of colon

  • gastric mucosa

  • Achilles tendon

  • tonsil

  • ganglionic eminence

  • olfactory zone of nasal mucosa

  • ventricular zone

  • skeletal muscle tissue
Top expressed in
  • uterus

  • yolk sac

  • bone marrow

  • embryo

  • embryo

  • blastocyst

  • morula

  • spermatid

  • thymus

  • spermatocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein domain specific binding
  • protein binding
  • protein heterodimerization activity
  • DNA binding
  • histone binding
  • RNA binding
Cellular component
  • membrane
  • chromosome
  • nucleoplasm
  • extracellular region
  • nuclear chromosome
  • nucleosome
  • extracellular exosome
  • nucleus
  • extracellular matrix
  • protein-containing complex
Biological process
  • telomere organization
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • protein heterotetramerization
  • negative regulation of megakaryocyte differentiation
  • CENP-A containing chromatin assembly
  • DNA replication-dependent chromatin assembly
  • rDNA heterochromatin assembly
  • negative regulation of gene expression, epigenetic
  • DNA-templated transcription, initiation
  • double-strand break repair via nonhomologous end joining
  • beta-catenin-TCF complex assembly
  • telomere capping
  • nucleosome assembly
  • regulation of gene silencing by miRNA
  • regulation of megakaryocyte differentiation
  • regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8363

319157

Ensembl

ENSG00000197238

ENSMUSG00000069274

UniProt

P62805

P62806

RefSeq (mRNA)

NM_021968

NM_175655

RefSeq (protein)
NP_003537
NP_003486
NP_003535
NP_003539
NP_003531

NP_003536

NP_291074
NP_783587
NP_783588
NP_835499
NP_835500

NP_001182350
NP_835515
NP_783585
NP_783586
NP_835582
NP_835583
NP_783583
NP_694813

Location (UCSC)Chr 6: 27.82 – 27.82 MbChr 13: 23.74 – 23.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene.[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197238 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069274 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Histone cluster 1, H4j". Retrieved 2012-03-12.

Further reading

  • Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (November 2000). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
  • Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (October 2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
  • Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  • Lusic M, Marcello A, Cereseto A, Giacca M (December 2003). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". The EMBO Journal. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
  • Heintz N, Zernik M, Roeder RG (June 1981). "The structure of the human histone genes: clustered but not tandemly repeated". Cell. 24 (3): 661–8. doi:10.1016/0092-8674(81)90092-1. PMID 6265100. S2CID 23027481.
  • Albig W, Doenecke D (December 1997). "The human histone gene cluster at the D6S105 locus". Human Genetics. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  • El Kharroubi A, Piras G, Zensen R, Martin MA (May 1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Molecular and Cellular Biology. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
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