HMCES

Protein-coding gene in the species Homo sapiens
HMCES
Identifiers
AliasesHMCES, C3orf37, SRAPD1, DC12, 5-hydroxymethylcytosine (hmC) binding, ES cell-specific, 5-hydroxymethylcytosine binding, ES cell specific
External IDsOMIM: 618288; MGI: 1914053; HomoloGene: 6636; GeneCards: HMCES; OMA:HMCES - orthologs
EC number3.4.-.-
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for HMCES
Genomic location for HMCES
Band3q21.3Start129,278,828 bp[1]
End129,306,186 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for HMCES
Genomic location for HMCES
Band6|6 D1Start87,890,917 bp[2]
End87,913,611 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • gastrocnemius muscle

  • ventricular zone

  • ganglionic eminence

  • mucosa of transverse colon

  • muscle of thigh

  • lymph node

  • apex of heart

  • secondary oocyte

  • left testis
Top expressed in
  • zygote

  • primary oocyte

  • secondary oocyte

  • embryo

  • tail of embryo

  • yolk sac

  • ventricular zone

  • granulocyte

  • genital tubercle

  • right kidney
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

56941

232210

Ensembl

ENSG00000183624

ENSMUSG00000030060

UniProt

Q96FZ2

Q8R1M0

RefSeq (mRNA)
NM_001006109
NM_020187
NM_001363881
NM_001370343
NM_001370344

NM_001370345

NM_173737

RefSeq (protein)
NP_001006109
NP_064572
NP_001350810
NP_001357272
NP_001357273

NP_001357274

NP_776098

Location (UCSC)Chr 3: 129.28 – 129.31 MbChr 6: 87.89 – 87.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

5-hydroxymethylcytosine binding, ES cell specific is a protein that in humans is encoded by the HMCES gene. [5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183624 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030060 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: 5-hydroxymethylcytosine binding, ES cell specific". Retrieved 2018-05-16.

Further reading

  • Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M (June 2014). "Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain". Neurobiol. Aging. 35 (6): 1334–44. doi:10.1016/j.neurobiolaging.2013.11.031. PMID 24387984. S2CID 25277574.
  • Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K (August 2014). "Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain". Neurobiol. Aging. 35 (8): 1850–4. doi:10.1016/j.neurobiolaging.2014.02.002. PMC 4066184. PMID 24679604.
  • Kraus TF, Guibourt V, Kretzschmar HA (July 2015). "5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing". J Neural Transm (Vienna). 122 (7): 1035–43. doi:10.1007/s00702-014-1346-4. PMID 25471351. S2CID 34905929.
  • Zhang LY, Li PL, Wang TZ, Zhang XC (October 2015). "Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer". Arch. Gynecol. Obstet. 292 (4): 891–7. doi:10.1007/s00404-015-3704-3. PMID 25827305. S2CID 24483457.
  • Biayna, Josep; Garcia-Cao, Isabel; Álvarez, Miguel M.; Salvadores, Marina; Espinosa-Carrasco, Jose; McCullough, Marcel; Supek, Fran; Stracker, Travis H. (2021-03-31). "Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells". PLOS Biology. 19 (3): e3001176. doi:10.1371/journal.pbio.3001176. PMC 8041192. PMID 33788831.</ref>


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