IMPG1

Protein-coding gene in the species Homo sapiens
IMPG1
Identifiers
AliasesIMPG1, GP147, IPM150, SPACR, VMD4, interphotoreceptor matrix proteoglycan 1, RP91
External IDsOMIM: 602870; MGI: 1926876; HomoloGene: 1201; GeneCards: IMPG1; OMA:IMPG1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for IMPG1
Genomic location for IMPG1
Band6q14.1Start75,921,114 bp[1]
End76,072,678 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for IMPG1
Genomic location for IMPG1
Band9 E1|9 43.99 cMStart80,220,612 bp[2]
End80,347,534 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • nucleus accumbens

  • secondary oocyte

  • caudate nucleus

  • gonad

  • putamen

  • right hemisphere of cerebellum

  • Brodmann area 9

  • right frontal lobe

  • right lung
Top expressed in
  • neural layer of retina

  • retinal pigment epithelium

  • gastrula

  • embryo

  • epithelium of lens

  • lumbar spinal ganglion

  • semi-lunar valve

  • left ventricle

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • extracellular matrix structural constituent
Cellular component
  • extracellular region
  • extracellular matrix
Biological process
  • visual perception
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3617

63859

Ensembl

ENSG00000112706

ENSMUSG00000032343

UniProt

Q17R60

Q8R1W8

RefSeq (mRNA)

NM_001563
NM_001282368

NM_022016

RefSeq (protein)

NP_001269297
NP_001554

NP_071299

Location (UCSC)Chr 6: 75.92 – 76.07 MbChr 9: 80.22 – 80.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interphotoreceptor matrix proteoglycan 1 is a protein that in humans is encoded by the IMPG1 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112706 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032343 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IMPG1 interphotoreceptor matrix proteoglycan 1".

Further reading

  • Felbor U, Gehrig A, Sauer CG, et al. (1998). "Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies". Cytogenet. Cell Genet. 81 (1): 12–7. doi:10.1159/000015001. PMID 9691169. S2CID 46766267.
  • Gehrig A, Felbor U, Kelsell RE, et al. (1998). "Assessment of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localised to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1)". J. Med. Genet. 35 (8): 641–5. doi:10.1136/jmg.35.8.641. PMC 1051388. PMID 9719369.
  • Acharya S, Rayborn ME, Hollyfield JG (1998). "Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis". Glycobiology. 8 (10): 997–1006. doi:10.1093/glycob/8.10.997. PMID 9719680.
  • Acharya S, Rodriguez IR, Moreira EF, et al. (1998). "SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan". J. Biol. Chem. 273 (47): 31599–606. doi:10.1074/jbc.273.47.31599. PMID 9813076.
  • Kuehn MH, Hageman GS (2000). "Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan". Matrix Biol. 18 (5): 509–18. doi:10.1016/S0945-053X(99)00043-8. PMID 10601738.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • van Lith-Verhoeven JJ, Hoyng CB, van den Helm B, et al. (2004). "The benign concentric annular macular dystrophy locus maps to 6p12.3-q16". Invest. Ophthalmol. Vis. Sci. 45 (1): 30–5. doi:10.1167/iovs.03-0392. PMID 14691150.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Abd El-Aziz MM, El-Ashry MF, Barragan I, et al. (2006). "Molecular genetic analysis of two functional candidate genes in the autosomal recessive retinitis pigmentosa, RP25, locus". Curr. Eye Res. 30 (12): 1081–7. doi:10.1080/02713680500351039. PMID 16354621. S2CID 26204316.


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