Protein-coding gene in the species Homo sapiens
INPP5A |
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Identifiers |
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Aliases | INPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A |
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External IDs | OMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs |
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Gene location (Human) |
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![Chromosome 10 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png) | Chr. | Chromosome 10 (human)[1] |
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| Band | 10q26.3 | Start | 132,537,787 bp[1] |
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End | 132,783,480 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F4 | Start | 138,969,025 bp[2] |
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End | 139,159,568 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - lateral nuclear group of thalamus
- saphenous vein
- myocardium of left ventricle
- middle temporal gyrus
- popliteal artery
- tibial arteries
- sperm
- external globus pallidus
- right ventricle
- gastric mucosa
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| Top expressed in | - Ileal epithelium
- cardiac muscle tissue of left ventricle
- lobe of cerebellum
- right ventricle
- cerebellar vermis
- interventricular septum
- plantaris muscle
- ascending aorta
- extensor digitorum longus muscle
- soleus muscle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/8/85/PBB_GE_INPP5A_203006_at_fs.png/250px-PBB_GE_INPP5A_203006_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - PH domain binding
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- protein binding
- hydrolase activity
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-polyphosphate 5-phosphatase activity
| Cellular component | - plasma membrane
- membrane
- intracellular anatomical structure
| Biological process | - inositol phosphate metabolic process
- phosphatidylinositol dephosphorylation
- inositol phosphate-mediated signaling
- inositol phosphate dephosphorylation
- dephosphorylation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001127363 NM_183144 NM_001355162 |
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RefSeq (protein) | | |
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NP_001120835 NP_001342091 NP_898967 |
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Location (UCSC) | Chr 10: 132.54 – 132.78 Mb | Chr 7: 138.97 – 139.16 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.[5][6]
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000068383 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025477 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID 8013665. S2CID 4936881.
- ^ a b "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".
Further reading
- Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase". J. Biol. Chem. 269 (25): 17305–10. doi:10.1016/S0021-9258(17)32555-3. PMID 8006039.
- Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization". Genomics. 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID 8808294.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I." J. Biol. Chem. 272 (3): 1786–90. doi:10.1074/jbc.272.3.1786. PMID 8999861.
- Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta". Biochemistry. 36 (49): 15363–70. doi:10.1021/bi9708085. PMID 9398266.
- Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.