Protein-coding gene in the species Homo sapiens
| INTS1 |
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| Identifiers |
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| Aliases | INTS1, INT1, NET28, integrator complex subunit 1, NDCAGF |
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| External IDs | OMIM: 611345; MGI: 1915760; HomoloGene: 53111; GeneCards: INTS1; OMA:INTS1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 7 (human)[1] |
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| | Band | 7p22.3 | Start | 1,470,277 bp[1] |
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| End | 1,504,389 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 5 (mouse)[2] |
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| | Band | 5|5 G2 | Start | 139,737,037 bp[2] |
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| End | 139,761,429 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - left testis
- right testis
- apex of heart
- right frontal lobe
- right hemisphere of cerebellum
- mucosa of transverse colon
- anterior pituitary
- right lobe of thyroid gland
- left lobe of thyroid gland
- right uterine tube
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| | Top expressed in | - tail of embryo
- genital tubercle
- spermatocyte
- neural layer of retina
- primary visual cortex
- superior frontal gyrus
- ventricular zone
- yolk sac
- muscle of thigh
- spermatid
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| | More reference expression data |
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| BioGPS | |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 7: 1.47 – 1.5 Mb | Chr 5: 139.74 – 139.76 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. [5]
Function
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164880 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029547 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Integrator complex subunit 1". Retrieved 2016-06-11.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
