INTS7

Protein-coding gene in the species Homo sapiens
INTS7
Identifiers
AliasesINTS7, C1orf73, INT7, integrator complex subunit 7
External IDsOMIM: 611350; MGI: 1924315; HomoloGene: 9136; GeneCards: INTS7; OMA:INTS7 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for INTS7
Genomic location for INTS7
Band1q32.3Start211,940,399 bp[1]
End212,035,557 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for INTS7
Genomic location for INTS7
Band1|1 H6Start191,307,748 bp[2]
End191,355,800 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • sperm

  • ventricular zone

  • gonad

  • testicle

  • right testis

  • left testis

  • islet of Langerhans

  • right lobe of liver

  • mucosa of transverse colon
Top expressed in
  • cumulus cell

  • primitive streak

  • endocardial cushion

  • maxillary prominence

  • hair follicle

  • spermatocyte

  • human fetus

  • mandibular prominence

  • medial ganglionic eminence

  • ureter
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integrator complex
  • chromosome
  • nucleoplasm
  • nucleus
  • cytoplasm
  • nuclear body
Biological process
  • cellular response to ionizing radiation
  • DNA damage checkpoint signaling
  • snRNA processing
  • cellular response to DNA damage stimulus
  • snRNA transcription by RNA polymerase II
  • snRNA 3'-end processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25896

77065

Ensembl

ENSG00000143493

ENSMUSG00000037461

UniProt

Q9NVH2

Q7TQK1

RefSeq (mRNA)

NM_001199809
NM_001199811
NM_001199812
NM_015434

NM_178632
NM_001306203
NM_001306204

RefSeq (protein)

NP_001186738
NP_001186740
NP_001186741
NP_056249

NP_001293132
NP_001293133
NP_848747

Location (UCSC)Chr 1: 211.94 – 212.04 MbChr 1: 191.31 – 191.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 7 is a protein that in humans is encoded by the INTS7 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143493 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037461 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
  6. ^ "Entrez Gene: INTS7 integrator complex subunit 7".

Further reading

  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


  • v
  • t
  • e