INTS8

Protein-coding gene in the species Homo sapiens
INTS8
Identifiers
AliasesINTS8, C8orf52, INT8, integrator complex subunit 8, NEDCHS
External IDsOMIM: 611351; MGI: 1919906; HomoloGene: 9888; GeneCards: INTS8; OMA:INTS8 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for INTS8
Genomic location for INTS8
Band8q22.1Start94,813,311 bp[1]
End94,881,746 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for INTS8
Genomic location for INTS8
Band4|4 A1Start11,199,158 bp[2]
End11,254,258 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gonad

  • Achilles tendon

  • ventricular zone

  • epithelium of colon

  • body of pancreas

  • canal of the cervix

  • ganglionic eminence

  • body of uterus

  • right ovary
Top expressed in
  • tail of embryo

  • genital tubercle

  • ventricular zone

  • otic placode

  • somite

  • saccule

  • medial ganglionic eminence

  • epiblast

  • superior cervical ganglion

  • hand
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integrator complex
  • nucleus
  • nucleoplasm
Biological process
  • snRNA processing
  • snRNA transcription by RNA polymerase II
  • snRNA 3'-end processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55656

72656

Ensembl

ENSG00000164941

ENSMUSG00000040738

UniProt

Q75QN2

Q80V86

RefSeq (mRNA)

NM_017864

NM_001159595
NM_178112

RefSeq (protein)

NP_060334

NP_001153067
NP_835213

Location (UCSC)Chr 8: 94.81 – 94.88 MbChr 4: 11.2 – 11.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 8 is a protein that in humans is encoded by the INTS8 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164941 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040738 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
  6. ^ "Entrez Gene: INTS8 integrator complex subunit 8".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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