Protein-coding gene in the species Homo sapiens
JAKMIP2 |
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Identifiers |
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Aliases | JAKMIP2, JAMIP2, NECC1, janus kinase and microtubule interacting protein 2 |
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External IDs | OMIM: 611197; MGI: 1923467; HomoloGene: 8866; GeneCards: JAKMIP2; OMA:JAKMIP2 - orthologs |
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Gene location (Human) |
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![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
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| Band | 5q32 | Start | 147,585,438 bp[1] |
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End | 147,782,775 bp[1] |
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Gene location (Mouse) |
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![Chromosome 18 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Ideogram_house_mouse_chromosome_18.svg/260px-Ideogram_house_mouse_chromosome_18.svg.png) | Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18|18 B3 | Start | 43,664,472 bp[2] |
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End | 43,820,838 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ventricular zone
- sural nerve
- middle temporal gyrus
- ganglionic eminence
- corpus callosum
- dorsal motor nucleus of vagus nerve
- entorhinal cortex
- prefrontal cortex
- postcentral gyrus
- Brodmann area 46
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| Top expressed in | - habenula
- piriform cortex
- lobe of cerebellum
- mammillary body
- anterior amygdaloid area
- ventromedial nucleus
- subiculum
- cerebellar vermis
- lateral hypothalamus
- primary motor cortex
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_014790 NM_001270934 NM_001270941 NM_001282282 |
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RefSeq (protein) | |
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NP_001257863 NP_001257870 NP_001269211 NP_055605 |
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Location (UCSC) | Chr 5: 147.59 – 147.78 Mb | Chr 18: 43.66 – 43.82 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Janus kinase and microtubule interacting protein 2 is a protein that in humans is encoded by the JAKMIP2 gene. [5]
Function
The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176049 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024502 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Janus kinase and microtubule interacting protein 2". Retrieved 2017-05-31.
Further reading
- Cruz-Garcia D, Vazquez-Martinez R, Peinado JR, Anouar Y, Tonon MC, Vaudry H, Castaño JP, Malagon MM (2007). "Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins". FEBS Lett. 581 (17): 3149–56. doi:10.1016/j.febslet.2007.06.002. PMID 17572408. S2CID 29349416.
- Koskinen LL, Einarsdottir E, Korponay-Szabo IR, Kurppa K, Kaukinen K, Sistonen P, Pocsai Z, Széles G, Adány R, Mäki M, Kere J, Saavalainen P (2009). "Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations". Tissue Antigens. 74 (5): 408–16. doi:10.1111/j.1399-0039.2009.01359.x. PMID 19845895.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.