JAKMIP2

Protein-coding gene in the species Homo sapiens
JAKMIP2
Identifiers
AliasesJAKMIP2, JAMIP2, NECC1, janus kinase and microtubule interacting protein 2
External IDsOMIM: 611197; MGI: 1923467; HomoloGene: 8866; GeneCards: JAKMIP2; OMA:JAKMIP2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for JAKMIP2
Genomic location for JAKMIP2
Band5q32Start147,585,438 bp[1]
End147,782,775 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for JAKMIP2
Genomic location for JAKMIP2
Band18|18 B3Start43,664,472 bp[2]
End43,820,838 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • sural nerve

  • middle temporal gyrus

  • ganglionic eminence

  • corpus callosum

  • dorsal motor nucleus of vagus nerve

  • entorhinal cortex

  • prefrontal cortex

  • postcentral gyrus

  • Brodmann area 46
Top expressed in
  • habenula

  • piriform cortex

  • lobe of cerebellum

  • mammillary body

  • anterior amygdaloid area

  • ventromedial nucleus

  • subiculum

  • cerebellar vermis

  • lateral hypothalamus

  • primary motor cortex
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

9832

76217

Ensembl

ENSG00000176049

ENSMUSG00000024502

UniProt

Q96AA8

D3YXK0

RefSeq (mRNA)

NM_014790
NM_001270934
NM_001270941
NM_001282282

NM_001163637

RefSeq (protein)

NP_001257863
NP_001257870
NP_001269211
NP_055605

NP_001157109

Location (UCSC)Chr 5: 147.59 – 147.78 MbChr 18: 43.66 – 43.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Janus kinase and microtubule interacting protein 2 is a protein that in humans is encoded by the JAKMIP2 gene. [5]

Function

The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176049 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024502 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Janus kinase and microtubule interacting protein 2". Retrieved 2017-05-31.

Further reading

  • Cruz-Garcia D, Vazquez-Martinez R, Peinado JR, Anouar Y, Tonon MC, Vaudry H, Castaño JP, Malagon MM (2007). "Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins". FEBS Lett. 581 (17): 3149–56. doi:10.1016/j.febslet.2007.06.002. PMID 17572408. S2CID 29349416.
  • Koskinen LL, Einarsdottir E, Korponay-Szabo IR, Kurppa K, Kaukinen K, Sistonen P, Pocsai Z, Széles G, Adány R, Mäki M, Kere J, Saavalainen P (2009). "Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations". Tissue Antigens. 74 (5): 408–16. doi:10.1111/j.1399-0039.2009.01359.x. PMID 19845895.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.