KDM7A

Protein-coding gene in the species Homo sapiens
KDM7A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3KV5, 3KV6, 3KV9, 3KVA, 3KVB, 3U78

Identifiers
AliasesKDM7A, JHDM1D, lysine demethylase 7A
External IDsMGI: 2443388; HomoloGene: 25281; GeneCards: KDM7A; OMA:KDM7A - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for KDM7A
Genomic location for KDM7A
Band7q34Start140,084,746 bp[1]
End140,176,983 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for KDM7A
Genomic location for KDM7A
Band6|6 B1Start39,113,557 bp[2]
End39,183,723 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • tendon of biceps brachii

  • glutes

  • bone marrow

  • skin of thigh

  • epithelium of nasopharynx

  • monocyte

  • buccal mucosa cell

  • skin of hip

  • bone marrow cells
Top expressed in
  • blood

  • zygote

  • granulocyte

  • Rostral migratory stream

  • vestibular sensory epithelium

  • secondary oocyte

  • left lung lobe

  • mesenteric lymph nodes

  • lobe of cerebellum

  • cerebellar vermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • 2-oxoglutarate-dependent dioxygenase activity
  • iron ion binding
  • histone H3-methyl-lysine-9 demethylase activity
  • histone H4-methyl-lysine-20 demethylase activity
  • dioxygenase activity
  • metal ion binding
  • methylated histone binding
  • histone H3-methyl-lysine-36 demethylase activity
  • oxidoreductase activity
  • histone H3-tri/di-methyl-lysine-27 demethylase activity
  • histone demethylase activity
  • zinc ion binding
Cellular component
  • nucleoplasm
  • nucleolus
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • histone H3-K27 demethylation
  • histone H3-K9 demethylation
  • histone H4-K20 demethylation
  • transcription, DNA-templated
  • nervous system development
  • positive regulation of transcription, DNA-templated
  • histone H3-K36 demethylation
  • midbrain development
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80853

338523

Ensembl

ENSG00000006459

ENSMUSG00000042599

UniProt

Q6ZMT4

Q3UWM4

RefSeq (mRNA)

NM_030647

NM_001033430

RefSeq (protein)

NP_085150

NP_001028602

Location (UCSC)Chr 7: 140.08 – 140.18 MbChr 6: 39.11 – 39.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006459 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042599 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lysine demethylase 7A". Retrieved 2016-04-09.

Further reading

  • Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K, Jing N, Chen CD (2010). "Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4". Cell Res. 20 (2): 154–65. doi:10.1038/cr.2010.5. PMID 20084082.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysine-specific demethylase 7A (KDM7A)
  • v
  • t
  • e