KIAA0157

Protein-coding gene in the species Homo sapiens
ABRAXAS2
Identifiers
AliasesABRAXAS2, ABRO1, KIAA0157, FAM175B, family with sequence similarity 175 member B, abraxas 2, BRISC complex subunit
External IDsOMIM: 611144; MGI: 1926116; HomoloGene: 12970; GeneCards: ABRAXAS2; OMA:ABRAXAS2 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ABRAXAS2
Genomic location for ABRAXAS2
Band10q26.13Start124,801,819 bp[1]
End124,836,667 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ABRAXAS2
Genomic location for ABRAXAS2
Band7|7 F3Start132,460,954 bp[2]
End132,486,840 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • middle temporal gyrus

  • Skeletal muscle tissue of biceps brachii

  • Brodmann area 23

  • gonad

  • deltoid muscle

  • gastrocnemius muscle

  • Achilles tendon

  • parietal pleura

  • visceral pleura
Top expressed in
  • Paneth cell

  • superior cervical ganglion

  • otolith organ

  • utricle

  • hand

  • ureter

  • foot

  • temporal muscle

  • facial motor nucleus

  • genital tubercle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • polyubiquitin modification-dependent protein binding
  • protein binding
Cellular component
  • cytoplasm
  • centrosome
  • spindle pole
  • BRISC complex
  • spindle pole centrosome
  • midbody
  • microtubule
  • cytoskeleton
  • nucleus
  • microtubule minus-end
  • cytosol
Biological process
  • chromosome segregation
  • cell division
  • mitotic spindle assembly
  • response to ischemia
  • protein K63-linked deubiquitination
  • cell cycle
  • attachment of spindle microtubules to kinetochore
  • protein deubiquitination
  • mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23172

109359

Ensembl

ENSG00000165660

ENSMUSG00000030965

UniProt

Q15018

Q3TCJ1

RefSeq (mRNA)

NM_032182

NM_198017

RefSeq (protein)

NP_115558

NP_932134

Location (UCSC)Chr 10: 124.8 – 124.84 MbChr 7: 132.46 – 132.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BRISC complex subunit Abro1 is a protein that in humans is encoded by the FAM175B gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165660 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030965 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  6. ^ "Entrez Gene: KIAA0157 KIAA0157".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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