KLC4

Protein-coding gene in Homo sapiens

KLC4
Identifiers
AliasesKLC4, KNSL8, bA387M24.3, kinesin light chain 4
External IDsMGI: 1922014; HomoloGene: 12584; GeneCards: KLC4; OMA:KLC4 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for KLC4
Genomic location for KLC4
Band6p21.1Start43,040,777 bp[1]
End43,075,095 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for KLC4
Genomic location for KLC4
Band17|17 CStart46,941,550 bp[2]
End46,956,948 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • mucosa of transverse colon

  • right hemisphere of cerebellum

  • mucosa of ileum

  • apex of heart

  • rectum

  • right uterine tube

  • pituitary gland

  • anterior pituitary

  • right lobe of thyroid gland
Top expressed in
  • intestinal villus

  • right kidney

  • jejunum

  • Ileal epithelium

  • duodenum

  • proximal tubule

  • yolk sac

  • neural layer of retina

  • large intestine

  • colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule motor activity
  • protein binding
Cellular component
  • cytoplasm
  • microtubule
  • cytoskeleton
  • kinesin complex
Biological process
  • metabolism
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89953

74764

Ensembl

ENSG00000137171

ENSMUSG00000003546

UniProt

Q9NSK0

Q9DBS5

RefSeq (mRNA)
NM_001289034
NM_001289035
NM_138343
NM_201521
NM_201522

NM_201523

NM_029091
NM_001357130

RefSeq (protein)
NP_001275963
NP_001275964
NP_612352
NP_958929
NP_958930

NP_958931
NP_001275963.1
NP_958929.1
NP_958930.1

NP_083367
NP_001344059

Location (UCSC)Chr 6: 43.04 – 43.08 MbChr 17: 46.94 – 46.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin light chain 4 is a protein that in humans is encoded by the KLC4 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137171 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003546 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KLC4 kinesin light chain 4".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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