LHX6

Protein-coding gene in the species Homo sapiens
LHX6
Identifiers
AliasesLHX6, LHX6.1, LIM homeobox 6, hLHX6
External IDsOMIM: 608215; MGI: 1306803; HomoloGene: 7401; GeneCards: LHX6; OMA:LHX6 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for LHX6
Genomic location for LHX6
Band9q33.2Start122,202,577 bp[1]
End122,229,626 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for LHX6
Genomic location for LHX6
Band2|2 BStart35,971,965 bp[2]
End35,995,420 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • subcutaneous adipose tissue

  • prefrontal cortex

  • anterior cingulate cortex

  • endothelial cell

  • orbitofrontal cortex

  • Brodmann area 46

  • ganglionic eminence

  • visceral pleura

  • parietal pleura
Top expressed in
  • medial ganglionic eminence

  • maxillary prominence

  • molar

  • entorhinal cortex

  • barrel cortex

  • CA3 field

  • perirhinal cortex

  • mandibular prominence

  • globus pallidus

  • female urethra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • metal ion binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular component
  • nucleus
Biological process
  • multicellular organism development
  • cerebral cortex GABAergic interneuron migration
  • cell differentiation
  • regulation of transcription, DNA-templated
  • cerebral cortex radially oriented cell migration
  • cerebral cortex tangential migration
  • cell maturation
  • transcription, DNA-templated
  • nervous system development
  • regulation of transcription by RNA polymerase II
  • forebrain neuron development
  • neuron differentiation
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26468

16874

Ensembl

ENSG00000106852

ENSMUSG00000026890

UniProt

Q9UPM6

Q9R1R0

RefSeq (mRNA)
NM_001242333
NM_001242334
NM_001242335
NM_014368
NM_199160

NM_001348190

NM_001083125
NM_001083126
NM_001083127
NM_008500
NM_001355125

RefSeq (protein)
NP_001229262
NP_001229263
NP_001229264
NP_055183
NP_954629

NP_001335119
NP_001229263.1

NP_001076594
NP_001076595
NP_001076596
NP_032526
NP_001342054

Location (UCSC)Chr 9: 122.2 – 122.23 MbChr 2: 35.97 – 36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.[5][6]

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106852 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026890 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kimura N, Ueno M, Nakashima K, Taga T (Oct 1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains". J Biochem. 126 (1): 180–7. doi:10.1093/oxfordjournals.jbchem.a022420. PMID 10393337.
  6. ^ a b "Entrez Gene: LHX6 LIM homeobox 6".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Estécio MR, Youssef EM, Rahal P, et al. (2006). "LHX6 is a sensitive methylation marker in head and neck carcinomas". Oncogene. 25 (36): 5018–26. doi:10.1038/sj.onc.1209509. PMID 16732332. S2CID 10501427.


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