LIMCH1

Protein-coding gene in the species Homo sapiens
LIMCH1
Identifiers
AliasesLIMCH1, LIMCH1A, LMO7B, LIM and calponin homology domains 1
External IDsOMIM: 617750; MGI: 1924819; HomoloGene: 18953; GeneCards: LIMCH1; OMA:LIMCH1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LIMCH1
Genomic location for LIMCH1
Band4p13Start41,359,607 bp[1]
End41,700,044 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for LIMCH1
Genomic location for LIMCH1
Band5|5 C3.1Start66,745,827 bp[2]
End67,057,158 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lower lobe of lung

  • internal globus pallidus

  • inferior ganglion of vagus nerve

  • olfactory bulb

  • corpus callosum

  • dorsal motor nucleus of vagus nerve

  • inferior olivary nucleus

  • subthalamic nucleus

  • superior vestibular nucleus

  • external globus pallidus
Top expressed in
  • sciatic nerve

  • left lung

  • right lung

  • left lung lobe

  • right lung lobe

  • retinal pigment epithelium

  • epithelium of lens

  • myocardium of ventricle

  • right ventricle

  • ankle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • actin binding
  • metal ion binding
  • myosin II head/neck binding
Cellular component
  • stress fiber
  • myosin II complex
  • cytoplasm
  • cytoskeleton
Biological process
  • actomyosin structure organization
  • positive regulation of protein phosphorylation
  • negative regulation of cell migration
  • positive regulation of stress fiber assembly
  • regulation of focal adhesion assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22998

77569

Ensembl

ENSG00000064042

ENSMUSG00000037736

UniProt

Q9UPQ0

Q3UH68

RefSeq (mRNA)
NM_001112717
NM_001112718
NM_001112719
NM_001112720
NM_001289122

NM_001289124
NM_014988
NM_001330672
NM_001330674
NM_001330784
NM_001330786
NM_001330787
NM_001330788
NM_001330789
NM_001330790
NM_001330791
NM_001330792
NM_001330793
NM_001330982
NM_001330983

NM_001001980
NM_001256122
NM_001368863

RefSeq (protein)
NP_001106188
NP_001106189
NP_001106190
NP_001106191
NP_001276051

NP_001276053
NP_001317601
NP_001317603
NP_001317713
NP_001317715
NP_001317716
NP_001317717
NP_001317718
NP_001317719
NP_001317720
NP_001317721
NP_001317722
NP_001317911
NP_001317912
NP_055803

NP_001001980
NP_001243051
NP_001355792
NP_001388339
NP_001388340

NP_001388341
NP_001388342
NP_001388343
NP_001388344
NP_001388345
NP_001388346
NP_001388347
NP_001388348
NP_001388349
NP_001388350
NP_001388351
NP_001388352
NP_001388353
NP_001388354
NP_001388355
NP_001388356
NP_001390437
NP_001390438

Location (UCSC)Chr 4: 41.36 – 41.7 MbChr 5: 66.75 – 67.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM and calponin homology domains-containing protein 1 is a protein that in humans is encoded by the LIMCH1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064042 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037736 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  6. ^ "Entrez Gene: DKFZP686A01247 hypothetical protein".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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