LINGO2

Protein-coding gene in the species Homo sapiens
LINGO2
Identifiers
AliasesLINGO2, LERN3, LRRN6C, leucine rich repeat and Ig domain containing 2
External IDsOMIM: 609793; MGI: 2442298; HomoloGene: 17621; GeneCards: LINGO2; OMA:LINGO2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for LINGO2
Genomic location for LINGO2
Band9p21.2-p21.1Start27,948,078 bp[1]
End28,670,286 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for LINGO2
Genomic location for LINGO2
Band4|4 A5Start35,706,647 bp[2]
End36,951,747 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • endothelial cell

  • middle temporal gyrus

  • Brodmann area 23

  • testicle

  • buccal mucosa cell

  • primary visual cortex

  • tail of epididymis

  • myometrium

  • body of uterus
Top expressed in
  • zygote

  • secondary oocyte

  • piriform cortex

  • respiratory epithelium

  • olfactory epithelium

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • ventromedial nucleus

  • primary motor cortex
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

158038

242384

Ensembl

ENSG00000174482

ENSMUSG00000045083

UniProt

Q7L985

Q3URE9

RefSeq (mRNA)

NM_001258282
NM_152570
NM_001354574
NM_001354575

NM_001165999
NM_001166000
NM_001166001
NM_175516

RefSeq (protein)

NP_001245211
NP_689783
NP_001341503
NP_001341504

NP_001159471
NP_001159472
NP_001159473
NP_780725

Location (UCSC)Chr 9: 27.95 – 28.67 MbChr 4: 35.71 – 36.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine rich repeat and Ig domain containing 2 is a protein that in humans is encoded by the LINGO2 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045083 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Leucine rich repeat and Ig domain containing 2". Retrieved 2014-03-31.

Further reading

  • Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, et al. (September 2010). "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency". Nature Genetics. 42 (9): 777–780. doi:10.1038/ng.644. PMID 20694011. S2CID 205356843.
  • Wu YW, Prakash KM, Rong TY, Li HH, Xiao Q, Tan LC, et al. (June 2011). "Lingo2 variants associated with essential tremor and Parkinson's disease". Human Genetics. 129 (6): 611–615. doi:10.1007/s00439-011-0955-3. PMID 21287203. S2CID 23493765.
  • Su FC, Chen CM, Chen YC, Wu YR (June 2012). "LINGO-2 polymorphism and the risk of Parkinson's disease in Taiwan". Parkinsonism & Related Disorders. 18 (5): 609–611. doi:10.1016/j.parkreldis.2011.11.013. PMID 22123311.
  • Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, et al. (August 2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". Journal of Bone and Mineral Research. 25 (8): 1821–1829. doi:10.1002/jbmr.62. PMC 3153352. PMID 20200978.
  • Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, et al. (October 2010). "LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease". Neurogenetics. 11 (4): 401–408. doi:10.1007/s10048-010-0241-x. PMC 3930084. PMID 20369371.
  • Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". The European Journal of Neuroscience. 18 (12): 3167–3182. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891. S2CID 42086715.


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