LRIT3

Protein-coding gene in the species Homo sapiens
LRIT3
Identifiers
AliasesLRIT3, CSNB1F, FIGLER4, leucine-rich repeat, Ig-like and transmembrane domains 3, leucine rich repeat, Ig-like and transmembrane domains 3
External IDsOMIM: 615004; MGI: 2685267; HomoloGene: 19426; GeneCards: LRIT3; OMA:LRIT3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LRIT3
Genomic location for LRIT3
Band4q25Start109,848,107 bp[1]
End109,872,315 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for LRIT3
Genomic location for LRIT3
Band3|3 G3Start129,581,530 bp[2]
End129,597,679 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • superior frontal gyrus

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • primary visual cortex

  • Brodmann area 9

  • renal cortex

  • tibial nerve

  • granulocyte

  • right frontal lobe
Top expressed in
  • neural layer of retina

  • embryo

  • secondary oocyte

  • primary oocyte

  • zygote

  • embryo

  • lens

  • renal cortex

  • proximal tubule

  • human kidney
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

345193

242235

Ensembl

ENSG00000183423

ENSMUSG00000093865

UniProt

Q3SXY7

W8DXL4

RefSeq (mRNA)

NM_198506

NM_001205102
NM_001287224

RefSeq (protein)

NP_940908

NP_001274153

Location (UCSC)Chr 4: 109.85 – 109.87 MbChr 3: 129.58 – 129.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 is a protein that in humans is encoded by the LRIT3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183423 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000093865 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3".

Further reading

  • Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
  • Kim SD, Liu JL, Roscioli T, Buckley MF, Yagnik G, Boyadjiev SA, Kim J (May 2012). "Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1". FEBS Letters. 586 (10): 1516–21. doi:10.1016/j.febslet.2012.04.010. PMC 3372856. PMID 22673519.
  • Zeitz C, Jacobson SG, Hamel CP, Bujakowska K, Neuillé M, Orhan E, Zanlonghi X, Lancelot ME, Michiels C, Schwartz SB, Bocquet B, Antonio A, Audier C, Letexier M, Saraiva JP, Luu TD, Sennlaub F, Nguyen H, Poch O, Dollfus H, Lecompte O, Kohl S, Sahel JA, Bhattacharya SS, Audo I (January 2013). "Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness". American Journal of Human Genetics. 92 (1): 67–75. doi:10.1016/j.ajhg.2012.10.023. PMC 3542465. PMID 23246293.


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