Protein-coding gene in the species Homo sapiens
LSM1 |
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Identifiers |
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Aliases | LSM1, CASM, YJL124C, LSM1 homolog, mRNA degradation associated |
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External IDs | OMIM: 607281; MGI: 1914457; HomoloGene: 40945; GeneCards: LSM1; OMA:LSM1 - orthologs |
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Gene location (Mouse) |
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![Chromosome 8 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png) | Chr. | Chromosome 8 (mouse)[1] |
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| Band | 8|8 A2 | Start | 26,275,316 bp[1] |
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End | 26,294,003 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - parotid gland
- hair follicle
- right ventricle
- renal medulla
- saphenous vein
- cardia
- monocyte
- vena cava
- external globus pallidus
- body of tongue
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| Top expressed in | - renal corpuscle
- medullary collecting duct
- epithelium of lens
- facial motor nucleus
- medial ganglionic eminence
- embryo
- neural tube
- ectoderm
- epiblast
- otic vesicle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/4/4b/PBB_GE_LSM1_203534_at_fs.png/250px-PBB_GE_LSM1_203534_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- RNA cap binding
- pre-mRNA binding
- mRNA binding
- RNA binding
| Cellular component | - cytosol
- P-body
- messenger ribonucleoprotein complex
- axon
- neuronal cell body
- dendrite
- nucleus
- cytoplasm
- mRNA cap binding complex
- Lsm1-7-Pat1 complex
| Biological process | - negative regulation of neuron differentiation
- deadenylation-dependent decapping of nuclear-transcribed mRNA
- RNA splicing, via transesterification reactions
- mRNA processing
- stem cell population maintenance
- RNA splicing
- exonucleolytic catabolism of deadenylated mRNA
- histone mRNA catabolic process
- nuclear-transcribed mRNA catabolic process
- RNA metabolic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | n/a | Chr 8: 26.28 – 26.29 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.[4][5][6]
Function
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[6]
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037296 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
- ^ Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T (Apr 2002). "Down-regulation of Lsm1 is involved in human prostate cancer progression". Br J Cancer. 86 (6): 940–6. doi:10.1038/sj.bjc.6600163. PMC 2364150. PMID 11953827.
- ^ a b "Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
Further reading
- Shimizu Y, Sugiyama H, Fujii Y, et al. (1997). "Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells". Am. J. Hematol. 54 (1): 1–11. doi:10.1002/(SICI)1096-8652(199701)54:1<1::AID-AJH1>3.0.CO;2-1. PMID 8980254.
- Schweinfest CW, Graber MW, Chapman JM, et al. (1997). "CaSm: an Sm-like protein that contributes to the transformed state in cancer cells". Cancer Res. 57 (14): 2961–5. PMID 9230209.
- Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
- Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
- Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
- Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Wichroski MJ, Robb GB, Rana TM (2006). "Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies". PLOS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
- Chu CY, Rana TM (2006). "Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54". PLOS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
- Streicher KL, Yang ZQ, Draghici S, Ethier SP (2007). "Transforming function of the LSM1 oncogene in human breast cancers with the 8p11−12 amplicon". Oncogene. 26 (14): 2104–14. doi:10.1038/sj.onc.1210002. PMC 2435249. PMID 17001308.