LST1

Protein-coding gene in the species Homo sapiens
LST1
Identifiers
AliasesLST1, B144, D6S49E, LST-1, leukocyte specific transcript 1
External IDsOMIM: 109170; MGI: 1096324; HomoloGene: 136814; GeneCards: LST1; OMA:LST1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for LST1
Genomic location for LST1
Band6p21.33Start31,586,124 bp[1]
End31,588,909 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for LST1
Genomic location for LST1
Band17 B1|17 18.59 cMStart35,404,071 bp[2]
End35,407,415 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • blood

  • bone marrow

  • bone marrow cells

  • spleen

  • periodontal fiber

  • trabecular bone

  • appendix

  • right lung
Top expressed in
  • granulocyte

  • spleen

  • blood

  • tibiofemoral joint

  • mesenteric lymph nodes

  • internal carotid artery

  • bone marrow

  • morula

  • thymus

  • external carotid artery
More reference expression data
BioGPS




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7940

16988

Ensembl
ENSG00000230791
ENSG00000226182
ENSG00000231048
ENSG00000204482
ENSG00000206433

ENSG00000223465
ENSG00000234514
ENSG00000235915

ENSMUSG00000073412

UniProt

O00453

O08843

RefSeq (mRNA)
NM_001166538
NM_007161
NM_205837
NM_205838
NM_205839

NM_205840

NM_010734

RefSeq (protein)
NP_001160010
NP_009092
NP_995309
NP_995310
NP_995311

NP_995312

NP_034864

Location (UCSC)Chr 6: 31.59 – 31.59 MbChr 17: 35.4 – 35.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the LST1 gene.[5][6][7]

References

  1. ^ a b c ENSG00000226182, ENSG00000231048, ENSG00000204482, ENSG00000206433, ENSG00000223465, ENSG00000234514, ENSG00000235915 GRCh38: Ensembl release 89: ENSG00000230791, ENSG00000226182, ENSG00000231048, ENSG00000204482, ENSG00000206433, ENSG00000223465, ENSG00000234514, ENSG00000235915 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073412 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
  6. ^ de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH (Jan 1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing". Genomics. 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.
  7. ^ "Entrez Gene: LST1 leukocyte specific transcript 1".

Further reading

  • Abraham LJ, Grimsley G, Zhang WJ, et al. (1992). "Polymorphism in the human B144 gene in different MHC haplotypes". Eur. J. Immunogenet. 19 (3): 165–8. doi:10.1111/j.1744-313X.1992.tb00055.x. PMID 1352700. S2CID 28280986.
  • Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region". Immunogenetics. 42 (5): 315–22. doi:10.1007/BF00179392. PMID 7590964. S2CID 19916860.
  • Pende D, Parolini S, Pessino A, et al. (1999). "Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells". J. Exp. Med. 190 (10): 1505–16. doi:10.1084/jem.190.10.1505. PMC 2195691. PMID 10562324.
  • Neville MJ, Campbell RD (2000). "Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6". DNA Seq. 8 (3): 155–60. doi:10.3109/10425179709034067. PMID 10668961.
  • Rollinger-Holzinger I, Eibl B, Pauly M, et al. (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. doi:10.4049/jimmunol.164.6.3169. PMID 10706707.
  • Yu X, Weissman SM (2000). "Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts". J. Biol. Chem. 275 (44): 34597–608. doi:10.1074/jbc.M004700200. PMID 10944527.
  • Raghunathan A, Sivakamasundari R, Wolenski J, et al. (2001). "Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells". Exp. Cell Res. 268 (2): 230–44. doi:10.1006/excr.2001.5290. PMID 11478849.
  • Ferlazzo G, Tsang ML, Moretta L, et al. (2002). "Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells". J. Exp. Med. 195 (3): 343–51. doi:10.1084/jem.20011149. PMC 2193591. PMID 11828009.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Castriconi R, Cantoni C, Della Chiesa M, et al. (2003). "Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4120–5. Bibcode:2003PNAS..100.4120C. doi:10.1073/pnas.0730640100. PMC 153058. PMID 12646700.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs.00955. PMID 15090600.
  • Marafioti T, Mancini C, Ascani S, et al. (2006). "Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease". Haematologica. 89 (8): 957–64. PMID 15339679.
  • Mulcahy H, O'Rourke KP, Adams C, et al. (2006). "LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection". Immunogenetics. 57 (12): 893–903. doi:10.1007/s00251-005-0057-2. PMID 16362817. S2CID 1615261.
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